Assessment of Structural Intolerance and Durability
General Structure Information 1mfv AMY1A probing the role of a mobile loop in human slaivary amylase: structural studies on the loop-deleted enzyme 2.0Å AUTH N.RAMASUBBU,C.RAGUNATH,P.J.MISHRATITL PROBING THE ROLE OF A MOBILE LOOP IN SUBSTRATETITL 2 BINDING AND ENZYME ACTIVITY OF HUMAN SALIVARYTITL 3 AMYLASE.REF J.MOL.BIOL. V. 325 1061 2003REFN ISSN 0022-2836PMID 12527308DOI 10.1016/S0022-2836(02)01326-8 Variant Set […]
General Structure Information 4nt5 VWF crystal structure of human von willebrand factor ctck domain 3.28Å AUTH Y.F.ZHOU,T.A.SPRINGERTITL HIGHLY REINFORCED STRUCTURE OF A C-TERMINAL DIMERIZATIONTITL 2 DOMAIN IN VON WILLEBRAND FACTOR.REF BLOOD V. 123 1785 2014REFN ISSN 0006-4971PMID 24394662DOI 10.1182/BLOOD-2013-11-523639 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bxe ALB human serum albumin complexed with diflunisal 2.95Å AUTH J.GHUMAN,P.A.ZUNSZAIN,I.PETITPAS,A.A.BHATTACHARYA,AUTH 2 M.OTAGIRI,S.CURRYTITL STRUCTURAL BASIS OF THE DRUG-BINDING SPECIFICITYTITL 2 OF HUMAN SERUM ALBUMIN.REF J.MOL.BIOL. V. 353 38 2005REFN ISSN 0022-2836PMID 16169013DOI 10.1016/J.JMB.2005.07.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ij9 AMY2A directed in situ elongation as a strategy to characterize the covalent glycosyl-enzyme catalytic intermediate of human pancreatic a-amylase 1.85Å AUTH R.ZHANG,C.LI,L.K.WILLIAMS,B.P.REMPEL,G.D.BRAYER,AUTH 2 S.G.WITHERSTITL DIRECTED IN SITU INHIBITOR ELONGATION AS ATITL 2 STRATEGY TO STRUCTURALLY CHARACTERIZE THE COVALENTTITL 3 GLYCOSYL-ENZYME INTERMEDIATE OF HUMAN PANCREATICTITL 4 ALPHA-AMYLASEREF BIOCHEMISTRY V. 48 10752 2009REFN […]
General Structure Information 4mxv LTA structure of lymphotoxin alpha bound to anti-lta fab 3.2Å AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110 Variant Set Distributions Mapped Variants
General Structure Information 1onq CD1A crystal structure of cd1a in complex with a sulfatide 2.15Å AUTH D.M.ZAJONC,M.A.ELSLIGER,L.TEYTON,I.A.WILSONTITL CRYSTAL STRUCTURE OF CD1A IN COMPLEX WITH A SULFATIDE SELFTITL 2 ANTIGEN AT A RESOLUTION OF 2.15 A.REF NAT.IMMUNOL. V. 4 808 2003REFN ISSN 1529-2908PMID 12833155DOI 10.1038/NI948 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4g0n RAF1 crystal structure of wt h-ras-gppnhp bound to the rbd of raf kinase 2.45Å AUTH S.K.FETICS,H.GUTERRES,B.M.KEARNEY,G.BUHRMAN,B.MA,R.NUSSINOV,AUTH 2 C.MATTOSTITL ALLOSTERIC EFFECTS OF THE ONCOGENIC RASQ61L MUTANT ONTITL 2 RAF-RBD.REF STRUCTURE V. 23 505 2015REFN ISSN 0969-2126PMID 25684575DOI 10.1016/J.STR.2014.12.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1nkp MYC crystal structure of myc-max recognizing dna 1.8Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Mapped Variants
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1axi GH1 structural plasticity at the hgh:hghbp interface 2.1Å AUTH S.ATWELL,M.ULTSCH,A.M.DE VOS,J.A.WELLSTITL STRUCTURAL PLASTICITY IN A REMODELED PROTEIN-PROTEINTITL 2 INTERFACE.REF SCIENCE V. 278 1125 1997REFN ISSN 0036-8075PMID 9353194DOI 10.1126/SCIENCE.278.5340.1125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants