Assessment of Structural Intolerance and Durability
General Structure Information 2w3c USO1 globular head region of the human general vesicular transport factor p115 2.22Å AUTH H.STRIEGL,Y.ROSKE,D.KUMMEL,U.HEINEMANNTITL UNUSUAL ARMADILLO FOLD IN THE HUMAN GENERAL VESICULARTITL 2 TRANSPORT FACTOR P115REF PLOS ONE V. 4 E4656 2009REFN ISSN 1932-6203PMID 19247479DOI 10.1371/JOURNAL.PONE.0004656 Variant Set Distributions Mapped Variants
General Structure Information 2gf0 DIRAS1 the crystal structure of the human diras1 gtpase in the inactive gdp bound state 1.9Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,X.YANG,G.SCHOCH,AUTH 2 J.ELKINS,O.GILEADI,E.SALAH,J.BRAY,L.WEN-HWA,AUTH 3 O.FEDOROV,F.E.NIESEN,F.VON DELFT,J.WEIGELT,AUTH 4 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN DIRAS1 GTPASETITL 2 IN THE INACTIVE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3uvh CLIC1 crystal structure analysis of e81m mutant of human clic1 1.84Å AUTH D.A.LEGG-ESILVA,S.FANUCCHI,I.A.ACHILONU,M.A.FERNANDES,AUTH 2 S.H.STOYCHEV,H.W.DIRRTITL CRYSTAL STRUCTURE ANALYSIS OF E81M MUTANT OF HUMAN CLIC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l81 AP4M1 crystal structure of adaptor protein complex 4 (ap-4) mu4 subunit c- terminal domain, in complex with a sorting peptide from the amyloid precursor protein (app) 1.6Å AUTH P.V.BURGOS,G.A.MARDONES,A.L.ROJAS,L.L.DASILVA,Y.PRABHU,AUTH 2 J.H.HURLEY,J.S.BONIFACINOTITL SORTING OF THE ALZHEIMERS DISEASE AMYLOID PRECURSORTITL 2 PROTEIN MEDIATED BY THE AP-4 COMPLEX.REF DEV.CELL V. 18 425 2010REFN ISSN […]
General Structure Information 4hpf KCNU1 structure of the human slo3 gating ring 3.4Å AUTH M.D.LEONETTI,P.YUAN,Y.HSIUNG,R.MACKINNONTITL FUNCTIONAL AND STRUCTURAL ANALYSIS OF THE HUMAN SLO3 PH- ANDTITL 2 VOLTAGE-GATED K+ CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 109 19274 2012REFN ISSN 0027-8424PMID 23129643DOI 10.1073/PNAS.1215078109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gry KIF2A crystal structure of the human kif2 motor domain in complex with adp 2.35Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF2 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gkh NPC1 npc1(ntd) 1.81Å AUTH H.J.KWON,L.ABI-MOSLEH,M.L.WANG,J.DEISENHOFER,J.L.GOLDSTEIN,AUTH 2 M.S.BROWN,R.E.INFANTETITL STRUCTURE OF N-TERMINAL DOMAIN OF NPC1 REVEALS DISTINCTTITL 2 SUBDOMAINS FOR BINDING AND TRANSFER OF CHOLESTEROL.REF CELL(CAMBRIDGE,MASS.) V. 137 1213 2009REFN ISSN 0092-8674PMID 19563754DOI 10.1016/J.CELL.2009.03.049 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c0j TRAPPC3 crystal structure of the bet3-trs33 heterodimer 2.2Å AUTH M.-S.KIM,M.-J.YI,K.-H.LEE,J.WAGNER,C.MUNGER,Y.-G.KIM,AUTH 2 M.WHITEWAY,M.CYGLER,B.-H.OH,M.SACHERTITL BIOCHEMICAL AND CRYSTALLOGRAPHIC STUDIES REVEAL A SPECIFICTITL 2 INTERACTION BETWEEN TRAPP SUBUNITS TRS33P AND BET3PREF TRAFFIC V. 6 1183 2005REFN ISSN 1398-9219PMID 16262728DOI 10.1111/J.1600-0854.2005.00352.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants