Assessment of Structural Intolerance and Durability
General Structure Information 2ova C8G x-ray structure of human complement protein c8gamma y83w mutant 1.5Å AUTH B.CHISWELL,L.L.LOVELACE,C.BRANNEN,E.A.ORTLUND,AUTH 2 L.LEBIODA,J.M.SODETZTITL STRUCTURAL FEATURES OF THE LIGAND BINDING SITE ONTITL 2 HUMAN COMPLEMENT PROTEIN C8GAMMA: A MEMBER OF THETITL 3 LIPOCALIN FAMILYREF BIOCHIM.BIOPHYS.ACTA V.1774 637 2007REFN ISSN 0006-3002PMID 17452033DOI 10.1016/J.BBAPAP.2007.03.004 Variant Set Distributions Mapped Variants
General Structure Information 2dh3 SLC3A2 crystal structure of human ed-4f2hc 2.8Å AUTH J.FORT,L.R.DE LA BALLINA,H.E.BURGHARDT,C.FERRER-COSTA,AUTH 2 J.TURNAY,C.FERRER-ORTA,I.USON,A.ZORZANO,J.FERNANDEZ-RECIO,AUTH 3 M.OROZCO,M.A.LIZARBE,I.FITA,M.PALACINTITL THE STRUCTURE OF HUMAN 4F2HC ECTODOMAIN PROVIDES A MODEL FORTITL 2 HOMODIMERIZATION AND ELECTROSTATIC INTERACTION WITH PLASMATITL 3 MEMBRANE.REF J.BIOL.CHEM. V. 282 31444 2007REFN ISSN 0021-9258PMID 17724034DOI 10.1074/JBC.M704524200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1bzk SLC4A1 structural studies on the effects of the deletion in the red cell anion exchanger (band3, ae1) associated with south east asian ovalocytosis. -1.0Å AUTH E.J.CHAMBERS,G.B.BLOOMBERG,S.M.RING,M.J.TANNERTITL STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETIONTITL 2 IN THE RED CELL ANION EXCHANGER (BAND 3, AE1)TITL 3 ASSOCIATED WITH SOUTH EAST ASIAN OVALOCYTOSIS.REF […]
General Structure Information 3fy7 CLIC3 crystal structure of homo sapiens clic3 1.95Å AUTH D.R.LITTLER,L.J.BROWN,S.N.BREIT,A.PERRAKIS,P.M.G.CURMITITL STRUCTURE OF HUMAN CLIC3 AT 2 A RESOLUTIONREF PROTEINS V. 78 1594 2010REFN ISSN 0887-3585PMID 20146363DOI 10.1002/PROT.22675 Variant Set Distributions Mapped Variants
General Structure Information 4der TTR crystal structure of the wild type ttr binding apigenin (ttrwt:api) 1.9Å AUTH D.B.TRIVELLA,C.V.DOS REIS,L.M.LIMA,D.FOGUEL,I.POLIKARPOVTITL FLAVONOID INTERACTIONS WITH HUMAN TRANSTHYRETIN: COMBINEDTITL 2 STRUCTURAL AND THERMODYNAMIC ANALYSIS.REF J.STRUCT.BIOL. V. 180 143 2012REFN ISSN 1047-8477PMID 22842046DOI 10.1016/J.JSB.2012.07.008 Variant Set Distributions Mapped Variants
General Structure Information 2hzq APOD crystal structure of human apolipoprotein d (apod) in complex with progesterone 1.8Å AUTH A.EICHINGER,A.NASREEN,H.J.KIM,A.SKERRATITL STRUCTURAL INSIGHT INTO THE DUAL LIGANDTITL 2 SPECIFICITY AND MODE OF HIGH DENSITY LIPOPROTEINTITL 3 ASSOCIATION OF APOLIPOPROTEIN D.REF J.BIOL.CHEM. V. 282 31068 2007REFN ISSN 0021-9258PMID 17699160DOI 10.1074/JBC.M703552200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1lhw SHBG crystal structure of the n-terminal lg-domain of shbg in complex with 2-methoxyestradiol 1.75Å AUTH G.V.AVVAKUMOV,I.GRISHKOVSKAYA,Y.A.MULLER,AUTH 2 G.L.HAMMONDTITL CRYSTAL STRUCTURE OF HUMAN SEX HORMONE-BINDINGTITL 2 GLOBULIN IN COMPLEX WITH 2-METHOXYESTRADIOLTITL 3 REVEALS THE MOLECULAR BASIS FOR HIGH AFFINITYTITL 4 INTERACTIONS WITH C-2 DERIVATIVES OF ESTRADIOL.REF J.BIOL.CHEM. V. 277 45219 2002REFN ISSN […]
General Structure Information 2bxe ALB human serum albumin complexed with diflunisal 2.95Å AUTH J.GHUMAN,P.A.ZUNSZAIN,I.PETITPAS,A.A.BHATTACHARYA,AUTH 2 M.OTAGIRI,S.CURRYTITL STRUCTURAL BASIS OF THE DRUG-BINDING SPECIFICITYTITL 2 OF HUMAN SERUM ALBUMIN.REF J.MOL.BIOL. V. 353 38 2005REFN ISSN 0022-2836PMID 16169013DOI 10.1016/J.JMB.2005.07.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kot GABARAP solution structure of human gaba receptor associated protein gabarap -1.0Å AUTH T.STANGLER,L.M.MAYR,D.WILLBOLDTITL SOLUTION STRUCTURE OF HUMAN GABA(A)TITL 2 RECEPTOR-ASSOCIATED PROTEIN GABARAP: IMPLICATIONSTITL 3 FOR BIOLGOICAL FUNCRION AND ITS REGULATION.REF J.BIOL.CHEM. V. 277 13363 2002REFN ISSN 0021-9258PMID 11875056DOI 10.1074/JBC.C200050200 Variant Set Distributions Mapped Variants
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants