Assessment of Structural Intolerance and Durability
General Structure Information 3kq4 GIF structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 4bgc KCNA3 t1 domain of the renal potassium channel kv1.3 1.2Å AUTH W.KREMER,M.WEYAND,A.WINKLMEIER,C.SCHREIER,H.R.KALBITZERTITL 1.2 A X-RAY STRUCTURE OF THE RENAL POTASSIUM CHANNEL KV1.3TITL 2 T1 DOMAIN.REF PROTEIN J. V. 32 533 2013REFN ISSN 1572-3887PMID 24114469DOI 10.1007/S10930-013-9513-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bb5 TCN2 structure of human transcobalamin in complex with cobalamin 3.2Å AUTH J.WUERGES,G.GARAU,S.GEREMIA,S.N.FEDOSOV,T.E.PETERSEN,AUTH 2 L.RANDACCIOTITL STRUCTURAL BASIS FOR MAMMALIAN VITAMIN B12 TRANSPORT BYTITL 2 TRANSCOBALAMIN.REF PROC.NATL.ACAD.SCI.USA V. 103 4386 2006REFN ISSN 0027-8424PMID 16537422DOI 10.1073/PNAS.0509099103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1z6x ARF4 structure of human adp-ribosylation factor 4 2.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hy5 RLBP1 crystal structure of cralbp 3.04Å AUTH X.HE,J.LOBSIGER,A.STOCKERTITL BOTHNIA DYSTROPHY IS CAUSED BY DOMINO-LIKETITL 2 REARRANGEMENTS IN CELLULAR RETINALDEHYDE-BINDINGTITL 3 PROTEIN MUTANT R234W.REF PROC.NATL.ACAD.SCI.USA V. 106 18545 2009REFN ISSN 0027-8424PMID 19846785DOI 10.1073/PNAS.0907454106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kmz FOLR2 human folate receptor beta (folr2) in complex with the folate 2.3Å AUTH A.S.WIBOWO,M.SINGH,K.M.REEDER,J.J.CARTER,A.R.KOVACH,W.MENG,AUTH 2 M.RATNAM,F.ZHANG,C.E.DANNTITL STRUCTURES OF HUMAN FOLATE RECEPTORS REVEAL BIOLOGICALTITL 2 TRAFFICKING STATES AND DIVERSITY IN FOLATE AND ANTIFOLATETITL 3 RECOGNITION.REF PROC.NATL.ACAD.SCI.USA V. 110 15180 2013REFN ISSN 0027-8424PMID 23934049DOI 10.1073/PNAS.1308827110 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kki TCN1 crystal structure of haptocorrin in complex with cncbl 2.35Å AUTH E.FURGER,D.C.FREI,R.SCHIBLI,E.FISCHER,A.E.PROTATITL STRUCTURAL BASIS FOR UNIVERSAL CORRINOID RECOGNITION BY THETITL 2 COBALAMIN TRANSPORT PROTEIN HAPTOCORRIN.REF J.BIOL.CHEM. V. 288 25466 2013REFN ISSN 0021-9258PMID 23846701DOI 10.1074/JBC.M113.483271 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3akm FABP2 x-ray structure of ifabp from human and rat with bound fluorescent fatty acid analogue 1.9Å AUTH A.J.K.LAGUERRE,J.WIELENS,M.W.PARKER,C.J.PORTER,M.J.SCANLONTITL CRYSTAL STRUCTURES OF HUMAN AND RAT INTESTINAL FATTY ACIDTITL 2 BINDING PROTEINS IN COMPLEX WITH 11-(DANSYLAMINO)UNDECANOICTITL 3 ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2vdy SERPINA6 crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol 2.3Å AUTH A.ZHOU,Z.WEI,P.L.STANLEY,R.J.READ,P.E.STEIN,R.W.CARRELLTITL THE S-TO-R TRANSITION OF CORTICOSTEROID-BINDING GLOBULINTITL 2 AND THE MECHANISM OF HORMONE RELEASE.REF J.MOL.BIOL. V. 380 244 2008REFN ISSN 0022-2836PMID 18513745DOI 10.1016/J.JMB.2008.05.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]