3ZBF.A | ROS1

General Structure Information 3zbf ROS1 structure of human ros1 kinase domain in complex with crizotinib 2.2Å AUTH M.M.AWAD,R.KATAYAMA,M.MCTIGUE,W.LIU,Y.DENG,A.BROOUN,AUTH 2 L.FRIBOULET,D.HUANG,M.D.FALK,S.TIMOFEEVSKI,K.D.WILNER,AUTH 3 E.L.LOCKERMAN,T.M.KHAN,S.MAHMOOD,J.F.GAINOR,S.R.DIGUMARTHY,AUTH 4 J.R.STONE,M.MINO-KENUDSON,J.G.CHRISTENSEN,J.IAFRATE,AUTH 5 J.A.ENGELMAN,A.T.SHAWTITL ACQUIRED RESISTANCE TO CRIZOTINIB FROM A MUTATION INTITL 2 CD74-ROS1REF N.ENGL.J.MED. V. 368 2395 2013REFN ISSN 0028-4793PMID 23724914DOI 10.1056/NEJMOA1215530 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

See Details
3EWU.B | UMPS

General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

See Details
2FGI.A | FGFR1

General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]

See Details
2JVN.A | PARP1

General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants

See Details
2X2U.A | RET

General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

See Details
2VCT.E | GSTA2

General Structure Information 2vct GSTA2 glutathione transferase a2-2 in complex with delta-4- andostrene-3-17-dione 2.1Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROIDTITL 2 ISOMERASE ACTIVITY IN ALPHA CLASS GLUTATHIONETITL 3 TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

See Details
1GUH.D | GSTA1

General Structure Information 1guh GSTA1 structure determination and refinement of human alpha class glutathione transferase a1-1, and a comparison with the mu and pi class enzymes 2.6Å AUTH I.SINNING,G.J.KLEYWEGT,S.W.COWAN,P.REINEMER,AUTH 2 H.W.DIRR,R.HUBER,G.L.GILLILAND,R.N.ARMSTRONG,X.JI,AUTH 3 P.G.BOARD,B.OLIN,B.MANNERVIK,T.A.JONESTITL STRUCTURE DETERMINATION AND REFINEMENT OF HUMANTITL 2 ALPHA CLASS GLUTATHIONE TRANSFERASE A1-1, AND ATITL 3 COMPARISON WITH THE MU AND PI CLASS […]

See Details
2F3M.E | GSTM1

General Structure Information 2f3m GSTM1 structure of human glutathione s-transferase m1a-1a complexed with 1-(s-(glutathionyl)-2,4,6- trinitrocyclohexadienate anion 2.7Å AUTH Y.PATSKOVSKY,L.PATSKOVSKA,S.C.ALMO,I.LISTOWSKYTITL TRANSITION STATE MODEL AND MECHANISM OFTITL 2 NUCLEOPHILIC AROMATIC SUBSTITUTION REACTIONSTITL 3 CATALYZED BY HUMAN GLUTATHIONE S-TRANSFERASETITL 4 M1A-1A.REF BIOCHEMISTRY V. 45 3852 2006REFN ISSN 0006-2960PMID 16548513DOI 10.1021/BI051823+ Variant Set Distributions Mapped Variants

See Details
1L5S.A | PYGL

General Structure Information 1l5s PYGL human liver glycogen phosphorylase complexed with uric acid, n-acetyl- beta-d-glucopyranosylamine, and cp-403,700 2.1Å AUTH J.L.EKSTROM,T.A.PAULY,M.D.CARTY,W.C.SOELLER,J.CULP,AUTH 2 D.E.DANLEY,D.J.HOOVER,J.L.TREADWAY,E.M.GIBBS,R.J.FLETTERICK,AUTH 3 Y.S.DAY,D.G.MYSZKA,V.L.RATHTITL STRUCTURE-ACTIVITY ANALYSIS OF THE PURINE BINDING SITE OFTITL 2 HUMAN LIVER GLYCOGEN PHOSPHORYLASE.REF CHEM.BIOL. V. 9 915 2002REFN ISSN 1074-5521PMID 12204691DOI 10.1016/S1074-5521(02)00186-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]

See Details
2COK.A | PARP1

General Structure Information 2cok PARP1 solution structure of brct domain of poly(adp-ribose) polymerase-1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF BRCT DOMAIN OFTITL 2 POLY(ADP-RIBOSE) POLYMERASE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

See Details