Assessment of Structural Intolerance and Durability
General Structure Information 3kex ERBB3 crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) 2.8Å AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1tev CMPK1 crystal structure of the human ump/cmp kinase in open conformation 2.1Å AUTH N.SEKULIC,S.ORT,M.KONRAD,A.LAVIETITL SUBSTRATE-INDUCED CONFORMATIONAL CHANGES IN HUMANTITL 2 UMP/CMP KINASE.REF J.BIOL.CHEM. V. 279 33882 2004REFN ISSN 0021-9258PMID 15163660DOI 10.1074/JBC.M401989200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zon TYK2 human tyk2 pseudokinase domain bound to a kinase inhibitor 2.15Å AUTH J.M.ELKINS,J.WANG,T.KROJER,P.SAVITSKY,R.CHALK,N.DAGA,AUTH 2 E.SALAH,G.BERRIDGE,S.PICAUD,F.VON DELFT,C.BOUNTRA,A.EDWARDS,AUTH 3 S.KNAPPTITL HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kxu TKT human transketolase in covalent complex with donor ketose d-fructose- 6-phosphate 0.98Å AUTH S.LUDTKE,P.NEUMANN,K.M.ERIXON,F.LEEPER,R.KLUGER,R.FICNER,AUTH 2 K.TITTMANNTITL SUB-ANGSTROM-RESOLUTION CRYSTALLOGRAPHY REVEALS PHYSICALTITL 2 DISTORTIONS THAT ENHANCE REACTIVITY OF A COVALENT ENZYMATICTITL 3 INTERMEDIATE.REF NAT CHEM V. 5 762 2013REFNPMID 23965678DOI 10.1038/NCHEM.1728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3hei EFNA1 ligand recognition by a-class eph receptors: crystal structures of the epha2 ligand-binding domain and the epha2/ephrin-a1 complex 2.0Å AUTH J.P.HIMANEN,Y.GOLDGUR,H.MIAO,E.MYSHKIN,H.GUO,M.BUCK,AUTH 2 M.NGUYEN,K.R.RAJASHANKAR,B.WANG,D.B.NIKOLOVTITL LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTALTITL 2 STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THETITL 3 EPHA2/EPHRIN-A1 COMPLEX.REF EMBO REP. V. 10 722 2009REFN ISSN 1469-221XPMID 19525919DOI […]
General Structure Information 2fy5 CHAT structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis 2.6Å AUTH A.R.KIM,R.J.RYLETT,B.H.SHILTONTITL SUBSTRATE BINDING AND CATALYTIC MECHANISM OF HUMANTITL 2 CHOLINE ACETYLTRANSFERASE.REF BIOCHEMISTRY V. 45 14621 2006REFN ISSN 0006-2960PMID 17144655DOI 10.1021/BI061536L Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2×10 EPHA2 crystal structure of the complete epha2 ectodomain 3.0Å AUTH E.SEIRADAKE,K.HARLOS,G.SUTTON,A.R.ARICESCU,AUTH 2 E.Y.JONESTITL AN EXTRACELLULAR STERIC SEEDING MECHANISM FOR EPH-TITL 2 EPHRIN SIGNALLING PLATFORM ASSEMBLYREF NAT.STRUCT.MOL.BIOL. V. 17 398 2010REFN ISSN 1545-9993PMID 20228801DOI 10.1038/NSMB.1782 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bi6 WEE1 wee1 kinase complex with inhibitor pd352396 2.2Å AUTH J.B.SMAILL,H.H.LEE,B.D.PALMER,A.M.THOMPSON,AUTH 2 C.J.SQUIRE,E.N.BAKER,R.J.BOOTH,A.KRAKER,K.HOOK,AUTH 3 W.A.DENNYTITL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SOLUBLE 8-SUBSTITUTEDTITL 3 4-(2-CHLOROPHENYL)-9-HYDROXYPYRROLO[3,4-TITL 4 C]CARBAZOLE-1,3(2H,6H)-DIONES AS INHIBITORS OF THETITL 5 WEE1 AND CHK1 CHECKPOINT KINASES.REF BIOORG.MED.CHEM.LETT. V. 18 929 2008REFN ISSN 0960-894XPMID 18191399DOI 10.1016/J.BMCL.2007.12.046 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4asx ACVR2A crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c 2.05Å AUTH E.WILLIAMS,A.CHAIKUAD,P.CANNING,P.MAHAJAN,C.D.O.COOPER,AUTH 2 A.BELTRAMI,T.KROJER,K.HUBER,F.BRACHER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA ( ACVR2A)TITL 2 KINASE DOMAIN IN COMPLEX WITH A BETA- CARBOLINE INHIBITORREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3kka EPHA1 co-crystal structure of the sam domains of epha1 and epha2 2.4Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CO-CRYSTAL STRUCTURE OF THE SAM DOMAINS OF HUMANTITL 2 EPHRIN TYPE-A RECEPTOR 1 AND HUMAN EPHRIN TYPE-ATITL 3 RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants