General Structure Information
| PDB ID | 3zon |
| HGNC Gene Label(s) | TYK2 |
| Structure Name | human tyk2 pseudokinase domain bound to a kinase inhibitor |
| Resolution | 2.15Å |
| Reference | AUTH J.M.ELKINS,J.WANG,T.KROJER,P.SAVITSKY,R.CHALK,N.DAGA,AUTH 2 E.SALAH,G.BERRIDGE,S.PICAUD,F.VON DELFT,C.BOUNTRA,A.EDWARDS,AUTH 3 S.KNAPPTITL HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITORREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 261 |
| Number Of SNVs | 73 |
| Number Of Permutations | 26269 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.07 |
| p-value | 0.02 |
COSMIC
| Number Of Residues | 261 |
| Number Of SNVs | 4 |
| Number Of Permutations | 83 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.167 |
| p-value | 0.741 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 73 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.278 |
| p-value | 0.34 |