Assessment of Structural Intolerance and Durability
General Structure Information 2a2d GALK2 x-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine 2.2Å AUTH J.B.THODEN,H.M.HOLDENTITL THE MOLECULAR ARCHITECTURE OF HUMANTITL 2 N-ACETYLGALACTOSAMINE KINASE.REF J.BIOL.CHEM. V. 280 32784 2005REFN ISSN 0021-9258PMID 16006554DOI 10.1074/JBC.M505730200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yhv PAK1 crystal structure of pak1 kinase domain with two point mutations (k299r, t423e) 1.8Å AUTH M.LEI,M.A.ROBINSON,S.C.HARRISONTITL THE ACTIVE CONFORMATION OF THE PAK1 KINASE DOMAINREF STRUCTURE V. 13 769 2005REFN ISSN 0969-2126PMID 15893667DOI 10.1016/J.STR.2005.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k8a PTK2 fragment-based discovery of focal adhesion kinase inhibitors 2.91Å AUTH U.GRADLER,J.BOMKE,D.MUSIL,V.DRESING,M.LEHMANN,G.HOLZEMANN,AUTH 2 H.GREINER,C.ESDAR,M.KRIER,T.HEINRICHTITL FRAGMENT-BASED DISCOVERY OF FOCAL ADHESION KINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 5401 2013REFN ISSN 0960-894XPMID 23973211DOI 10.1016/J.BMCL.2013.07.050 Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ny0 PTK2 crystal structure of ferm domain of human focal adhesion kinase 2.8Å AUTH K.BRAMI-CHERRIER,N.GERVASI,D.ARSENIEVA,K.WALKIEWICZ,AUTH 2 M.C.BOUTTERIN,A.ORTEGA,P.G.LEONARD,B.SEANTIER,L.GASMI,AUTH 3 T.BOUCEBA,G.KADARE,J.A.GIRAULT,S.T.AROLDTITL FAK DIMERIZATION CONTROLS ITS KINASE-DEPENDENT FUNCTIONS ATTITL 2 FOCAL ADHESIONS.REF EMBO J. V. 33 356 2014REFN ISSN 0261-4189PMID 24480479DOI 10.1002/EMBJ.201386399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1k05 PTK2 crystal structure of the focal adhesion targeting domain of focal adhesion kinase 2.9Å AUTH S.T.AROLD,M.K.HOELLERER,M.E.NOBLETITL THE STRUCTURAL BASIS OF LOCALIZATION AND SIGNALINGTITL 2 BY THE FOCAL ADHESION TARGETING DOMAIN.REF STRUCTURE V. 10 319 2002REFN ISSN 0969-2126PMID 12005431DOI 10.1016/S0969-2126(02)00717-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4ic8 MAPK7 crystal structure of the apo erk5 kinase domain 2.8Å AUTH G.GLATZ,G.GOGL,A.ALEXA,A.REMENYITITL STRUCTURAL MECHANISM FOR THE SPECIFIC ASSEMBLY ANDTITL 2 ACTIVATION OF THE EXTRACELLULAR SIGNAL REGULATED KINASE 5TITL 3 (ERK5) MODULE.REF J.BIOL.CHEM. V. 288 8596 2013REFN ISSN 0021-9258PMID 23382384DOI 10.1074/JBC.M113.452235 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]