General Structure Information
| PDB ID | 4ic8 |
| HGNC Gene Label(s) | MAPK7 |
| Structure Name | crystal structure of the apo erk5 kinase domain |
| Resolution | 2.8Å |
| Reference | AUTH G.GLATZ,G.GOGL,A.ALEXA,A.REMENYITITL STRUCTURAL MECHANISM FOR THE SPECIFIC ASSEMBLY ANDTITL 2 ACTIVATION OF THE EXTRACELLULAR SIGNAL REGULATED KINASE 5TITL 3 (ERK5) MODULE.REF J.BIOL.CHEM. V. 288 8596 2013REFN ISSN 0021-9258PMID 23382384DOI 10.1074/JBC.M113.452235 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 325 |
| Number Of SNVs | 80 |
| Number Of Permutations | 13999 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.187 |
| p-value | 0.012 |
COSMIC
| Number Of Residues | 325 |
| Number Of SNVs | 3 |
| Number Of Permutations | 135 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.667 |
| p-value | 0.388 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
