General Structure Information
| PDB ID | 1yhv |
| HGNC Gene Label(s) | PAK1 |
| Structure Name | crystal structure of pak1 kinase domain with two point mutations (k299r, t423e) |
| Resolution | 1.8Å |
| Reference | AUTH M.LEI,M.A.ROBINSON,S.C.HARRISONTITL THE ACTIVE CONFORMATION OF THE PAK1 KINASE DOMAINREF STRUCTURE V. 13 769 2005REFN ISSN 0969-2126PMID 15893667DOI 10.1016/J.STR.2005.03.007 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 24 |
| Number Of Permutations | 3447 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.207 |
| p-value | 0.332 |
COSMIC
| Number Of Residues | 293 |
| Number Of SNVs | 3 |
| Number Of Permutations | 142 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.667 |
| p-value | 0.111 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.543 |
| p-value | 0.095 |