General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tl5 PIK3CG discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer 2.79Å AUTH D.P.SUTHERLIN,L.BAO,M.BERRY,G.CASTANEDO,I.CHUCKOWREE,AUTH 2 J.DOTSON,A.FOLKS,L.FRIEDMAN,R.GOLDSMITH,J.GUNZNER,T.HEFFRON,AUTH 3 J.LESNICK,C.LEWIS,S.MATHIEU,J.MURRAY,J.NONOMIYA,J.PANG,AUTH 4 N.PEGG,W.W.PRIOR,L.ROUGE,L.SALPHATI,D.SAMPATH,Q.TIAN,V.TSUI,AUTH 5 N.C.WAN,S.WANG,B.WEI,C.WIESMANN,P.WU,B.Y.ZHU,A.OLIVEROTITL DISCOVERY OF A POTENT, SELECTIVE, AND ORALLY AVAILABLE CLASSTITL 2 I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K)/MAMMALIAN […]
General Structure Information 4nw5 RPS6KA3 rsk2 n-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 1.94Å AUTH A.COSTALES,M.MATHUR,S.RAMURTHY,J.LAN,S.SUBRAMANIAN,R.JAIN,AUTH 2 G.ATALLAH,L.SETTI,M.LINDVALL,B.A.APPLETON,E.ORNELAS,AUTH 3 P.FEUCHT,B.WARNE,L.DOYLE,S.E.BASHAM,I.ARONCHIK,AUTH 4 A.B.JEFFERSON,C.M.SHAFERTITL 2-AMINO-7-SUBSTITUTED BENZOXAZOLE ANALOGS AS POTENT RSK2TITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 24 1592 2014REFN ISSN 0960-894XPMID 24534486DOI 10.1016/J.BMCL.2014.01.058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3npc MAPK9 crystal structure of jnk2 complexed with birb796 2.35Å AUTH A.KUGLSTATTER,M.GHATE,S.TSING,A.G.VILLASENOR,D.SHAW,AUTH 2 J.W.BARNETT,M.F.BROWNERTITL X-RAY CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH THE P38ALPHATITL 2 INHIBITOR BIRB796: INSIGHTS INTO THE RATIONAL DESIGN OFTITL 3 DFG-OUT BINDING MAP KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 20 5217 2010REFN ISSN 0960-894XPMID 20655210DOI 10.1016/J.BMCL.2010.06.157 Variant Set Distributions Ripley’s K […]
General Structure Information 3qtz CDK2 cdk2 in complex with inhibitor rc-2-36 2.0Å AUTH E.SCHONBRUNN,S.BETZI,R.ALAM,M.P.MARTIN,A.BECKER,H.HAN,AUTH 2 R.FRANCIS,R.CHAKRASALI,S.JAKKARAJ,A.KAZI,S.M.SEBTI,AUTH 3 C.L.CUBITT,A.W.GEBHARD,L.A.HAZLEHURST,J.S.TASH,G.I.GEORGTITL DEVELOPMENT OF HIGHLY POTENT AND SELECTIVE DIAMINOTHIAZOLETITL 2 INHIBITORS OF CYCLIN-DEPENDENT KINASES.REF J.MED.CHEM. V. 56 3768 2013REFN ISSN 0022-2623PMID 23600925DOI 10.1021/JM301234K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants