General Structure Information
| PDB ID | 3qtz |
| HGNC Gene Label(s) | CDK2 |
| Structure Name | cdk2 in complex with inhibitor rc-2-36 |
| Resolution | 2.0Å |
| Reference | AUTH E.SCHONBRUNN,S.BETZI,R.ALAM,M.P.MARTIN,A.BECKER,H.HAN,AUTH 2 R.FRANCIS,R.CHAKRASALI,S.JAKKARAJ,A.KAZI,S.M.SEBTI,AUTH 3 C.L.CUBITT,A.W.GEBHARD,L.A.HAZLEHURST,J.S.TASH,G.I.GEORGTITL DEVELOPMENT OF HIGHLY POTENT AND SELECTIVE DIAMINOTHIAZOLETITL 2 INHIBITORS OF CYCLIN-DEPENDENT KINASES.REF J.MED.CHEM. V. 56 3768 2013REFN ISSN 0022-2623PMID 23600925DOI 10.1021/JM301234K |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 294 |
| Number Of SNVs | 34 |
| Number Of Permutations | 16749 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.193 |
| p-value | 0.316 |
COSMIC
| Number Of Residues | 294 |
| Number Of SNVs | 3 |
| Number Of Permutations | 66 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.667 |
| p-value | 0.217 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.722 |
| p-value | 0.149 |