Assessment of Structural Intolerance and Durability
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 3v5l ITK crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542 1.86Å AUTH L.R.MCLEAN,Y.ZHANG,N.ZAIDI,X.BI,R.WANG,R.DHARANIPRAGADA,AUTH 2 J.G.JURCAK,T.A.GILLESPY,Z.ZHAO,K.Y.MUSICK,Y.M.CHOI,AUTH 3 M.BARRAGUE,J.PEPPARD,M.SMICKER,M.DUGUID,A.PARKAR,J.FORDHAM,AUTH 4 D.KOMINOSTITL X-RAY CRYSTALLOGRAPHIC STRUCTURE-BASED DESIGN OF SELECTIVETITL 2 THIENOPYRAZOLE INHIBITORS FOR INTERLEUKIN-2-INDUCIBLETITL 3 TYROSINE KINASE.REF BIOORG.MED.CHEM.LETT. V. 22 3296 2012REFN ISSN 0960-894XPMID 22464456DOI 10.1016/J.BMCL.2012.03.016 Variant Set Distributions Ripley’s […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 3sxs BMX crystal structure of bmx non-receptor tyrosine kinase complexed with pp2 1.89Å AUTH J.MUCKELBAUER,J.S.SACK,N.AHMED,J.BURKE,C.Y.CHANG,M.GAO,AUTH 2 J.TINO,D.XIE,A.J.TEBBENTITL X-RAY CRYSTAL STRUCTURE OF BONE MARROW KINASE IN THE XTITL 2 CHROMOSOME: A TEC FAMILY KINASE.REF CHEM.BIOL.DRUG DES. V. 78 739 2011REFN ISSN 1747-0277PMID 21883956DOI 10.1111/J.1747-0285.2011.01230.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]