General Structure Information
| PDB ID | 3v5l |
| HGNC Gene Label(s) | ITK |
| Structure Name | crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542 |
| Resolution | 1.86Å |
| Reference | AUTH L.R.MCLEAN,Y.ZHANG,N.ZAIDI,X.BI,R.WANG,R.DHARANIPRAGADA,AUTH 2 J.G.JURCAK,T.A.GILLESPY,Z.ZHAO,K.Y.MUSICK,Y.M.CHOI,AUTH 3 M.BARRAGUE,J.PEPPARD,M.SMICKER,M.DUGUID,A.PARKAR,J.FORDHAM,AUTH 4 D.KOMINOSTITL X-RAY CRYSTALLOGRAPHIC STRUCTURE-BASED DESIGN OF SELECTIVETITL 2 THIENOPYRAZOLE INHIBITORS FOR INTERLEUKIN-2-INDUCIBLETITL 3 TYROSINE KINASE.REF BIOORG.MED.CHEM.LETT. V. 22 3296 2012REFN ISSN 0960-894XPMID 22464456DOI 10.1016/J.BMCL.2012.03.016 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 238 |
| Number Of SNVs | 52 |
| Number Of Permutations | 7239 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.165 |
| p-value | 0.015 |
COSMIC
| Number Of Residues | 238 |
| Number Of SNVs | 5 |
| Number Of Permutations | 268 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.169 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.154 |
| p-value | 0.28 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
