Assessment of Structural Intolerance and Durability
General Structure Information 2y43 RAD18 rad18 ubiquitin ligase ring domain structure 1.8Å AUTH A.HUANG,R.G.HIBBERT,R.N.DE JONG,D.DAS,T.K.SIXMA,R.BOELENSTITL SYMMETRY AND ASYMMETRY OF THE RING-RING DIMER OF RAD18.REF J.MOL.BIOL. V. 410 424 2011REFN ISSN 0022-2836PMID 21549715DOI 10.1016/J.JMB.2011.04.051 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dkz GAREM solution structure of the sam_pnt-domain of the hypothetical protein loc64762 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HYPOTHETICAL PROTEIN LOC64762REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ejm MCCC1 solution structure of ruh-072, an apo-biotnyl domain form human acetyl coenzyme a carboxylase -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-072, AN APO-BIOTNYLTITL 2 DOMAIN FORM HUMAN ACETYL COENZYME A CARBOXYLASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pny IDI2 structure of human isopentenyl-diphosphate delta-isomerase 2 1.81Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN ISOPENTENYL-DIPHOSPHATETITL 2 DELTA-ISOMERASE 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yxm PECR crystal structure of peroxisomal trans 2-enoyl coa reductase 1.9Å AUTH A.JANSSON,S.NG,C.ARROWSMITH,S.SHARMA,A.M.EDWARDS,AUTH 2 F.VON DELFT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF PERIXOMAL TRANS 2-ENOYL COATITL 2 REDUCTASE (PECRA)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vcy MECR crystal structure of 2-enoyl thioester reductase of human fas ii 2.41Å AUTH Z.J.CHEN,R.PUDAS,S.SHARMA,O.S.SMART,A.H.JUFFER,AUTH 2 J.K.HILTUNEN,R.K.WIERENGA,A.M.HAAPALAINENTITL STRUCTURAL ENZYMOLOGICAL STUDIES OF 2-ENOYLTITL 2 THIOESTER REDUCTASE OF THE HUMAN MITOCHONDRIAL FASTITL 3 II PATHWAY: NEW INSIGHTS INTO ITS SUBSTRATETITL 4 RECOGNITION PROPERTIES.REF J.MOL.BIOL. V. 379 830 2008REFN ISSN 0022-2836PMID 18479707DOI 10.1016/J.JMB.2008.04.041 Variant Set […]
General Structure Information 2ean CNKSR2 solution structure of the n-terminal sam-domain of human kiaa0902 protein (connector enhancer of kinase suppressor of ras 2) -1.0Å AUTH A.K.GORONCY,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 HUMAN KIAA0902 PROTEIN (CONNECTOR ENHANCER OFTITL 3 KINASE SUPPRESSOR OF RAS 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3d7c KAT2A crystal structure of the bromodomain of human gcn5, the general control of amino-acid synthesis protein 5-like 2 2.06Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2c2n MCAT structure of human mitochondrial malonyltransferase 1.55Å AUTH G.BUNKOCZI,S.MISQUITTA,X.WU,W.H.LEE,A.ROJKOVA,G.KOCHAN,AUTH 2 K.L.KAVANAGH,U.OPPERMANN,S.SMITHTITL STRUCTURAL BASIS FOR DIFFERENT SPECIFICITIES OFTITL 2 ACYLTRANSFERASES ASSOCIATED WITH THE HUMAN CYTOSOLIC ANDTITL 3 MITOCHONDRIAL FATTY ACID SYNTHASES.REF CHEM.BIOL. V. 16 667 2009REFN ISSN 1074-5521PMID 19549604DOI 10.1016/J.CHEMBIOL.2009.04.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants