1YXM.D | PECR – ASTRID

1YXM.D | PECR

General Structure Information

PDB ID	1yxm
HGNC Gene Label(s)	PECR
Structure Name	crystal structure of peroxisomal trans 2-enoyl coa reductase
Resolution	1.9Å
Reference	AUTH A.JANSSON,S.NG,C.ARROWSMITH,S.SHARMA,A.M.EDWARDS,AUTH 2 F.VON DELFT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF PERIXOMAL TRANS 2-ENOYL COATITL 2 REDUCTASE (PECRA)REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	291
Number Of SNVs	84
Number Of Permutations	45587
Optimal Distance Threshold	10.0
K Statistic	0.066
p-value	0.927

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:216946436	rs540483371	Y>C	D:10	(17.63, 32.40, 20.57)
2:216946437		Y>H	D:10	(17.63, 32.40, 20.57)
2:216946415	rs148596575	Q>R	D:17	(14.99, 28.77, 3.32)
2:216946412		G>D	D:18	(10.91, 29.53, 1.16)
2:216946413		G>C	D:18	(10.91, 29.53, 1.16)
2:216946398		V>L	D:23	(2.48, 39.74, 8.85)
2:216946391	rs370096306	G>D	D:25	(0.74, 44.31, 11.68)
2:216946382	rs201164160	T>R	D:28	(5.00, 48.27, 14.36)
2:216946365	rs149826053	I>F	D:34	(7.20, 38.61, 13.70)
2:216946354		E>D	D:37	(12.65, 35.92, 13.60)
2:216946352		L>P	D:38	(9.84, 35.24, 9.39)
2:216946349		L>P	D:39	(13.02, 37.86, 6.63)
2:216931238	rs139848375	S>N	D:43	(10.66, 33.69, 4.93)
2:216931236		N>D	D:44	(9.43, 35.01, 1.49)
2:216931217	rs143524258	R>H	D:50	(-4.92, 51.22, 8.87)
2:216931218	rs201983152	R>C	D:50	(-4.92, 51.22, 8.87)
2:216931193	rs149302775	A>V	D:58	(9.24, 49.02, 7.27)
2:216931181		L>Q	D:62	(13.05, 45.01, 7.05)
2:216931182		L>M	D:62	(13.05, 45.01, 7.05)
2:216931137		I>V	D:77	(0.25, 44.82, 0.74)
2:216931133	rs545617034	Q>P	D:78	(-2.66, 49.64, 2.18)
2:216931131		C>R	D:79	(-5.03, 46.11, 4.30)
2:216931121	rs148766107	R>Q	D:82	(-13.11, 47.32, 9.86)
2:216931122	rs370330623	R>W	D:82	(-13.11, 47.32, 9.86)
2:216931109	rs147446138	E>V	D:86	(-9.03, 45.73, 1.58)
2:216930195		N>K	D:88	(-10.19, 38.86, -0.69)
2:216930192		N>K	D:89	(-6.46, 41.41, -2.34)
2:216930191	rs139183448	L>V	D:90	(-3.48, 40.69, 0.99)
2:216930188		V>F	D:91	(-4.68, 36.60, -0.21)
2:216930170	rs200767983 COSM1016209	T>A	D:97	(4.09, 37.39, -5.77)
2:216930166	rs201319769	F>C	D:98	(5.80, 35.17, -3.00)
2:216930139	rs536985761	N>S	D:107	(-0.71, 41.68, 14.95)
2:216930118		S>C	D:114	(-12.22, 52.82, 28.30)
2:216930107		H>D	D:118	(-17.14, 56.41, 29.16)
2:216930091		G>V	D:123	(-15.55, 51.55, 19.25)
2:216930086	rs41272675	H>D	D:125	(-18.95, 47.90, 16.40)
2:216930061	COSM1683149	T>M	D:133	(-14.02, 40.30, 12.16)
2:216930056		T>P	D:135	(-8.74, 37.26, 12.41)
2:216923679	rs1429148	E>K	D:149	(-5.68, 22.31, -0.57)
2:216923675		H>R	D:150	(-1.99, 23.26, -0.59)
2:216923657		N>S	D:156	(-3.77, 34.16, 16.16)
2:216923648		V>A	D:159	(-4.22, 39.56, 25.00)
2:216923643		T>A	D:161	(-7.93, 36.42, 28.19)
2:216923627		P>L	D:166	(-10.16, 45.54, 33.23)
2:216923628		P>T	D:166	(-10.16, 45.54, 33.23)
2:216923621		A>G	D:168	(-10.64, 46.81, 27.68)
2:216923619	rs62001895	V>L	D:169	(-14.55, 45.33, 27.50)
2:216916252	rs560544620	R>G	D:175	(-7.76, 40.21, 21.41)
2:216916245		G>D	D:177	(-12.66, 34.95, 20.45)
2:216916243	rs374129165	V>I	D:178	(-9.45, 34.96, 18.55)
2:216916240		Y>D	D:179	(-8.10, 30.71, 22.97)
2:216916234		L>F	D:181	(-11.64, 31.23, 16.01)
2:216916228		K>E	D:183	(-10.14, 26.41, 20.83)
2:216916213	rs147716747	E>Q	D:188	(-13.56, 23.37, 11.01)
2:216916207	rs62001894	A>P	D:190	(-7.36, 19.25, 10.76)
2:216916193		I>M	D:194	(-4.49, 23.87, 8.96)
2:216916191	rs200015845	R>Q	D:195	(-0.09, 23.88, 12.94)
2:216916192		R>W	D:195	(-0.09, 23.88, 12.94)
2:216916185	rs537319828	N>S	D:197	(-1.62, 28.09, 17.57)
2:216916176		A>D	D:200	(-0.14, 36.26, 24.65)
2:216916174		P>A	D:201	(1.38, 39.36, 24.17)
2:216914095	rs141598677	G>E	D:202	(2.08, 41.68, 27.25)
2:216914079	rs148712165	Q>H	D:207	(9.10, 53.89, 19.55)
2:216914062		Y>C	D:213	(-1.13, 52.68, 26.17)
2:216914050		G>A	D:217	(2.40, 55.95, 28.65)
2:216914029		S>C	D:224	(4.29, 48.18, 34.46)
2:216914023	rs201636518	Q>R	D:226	(5.62, 47.84, 40.40)
2:216914014		P>L	D:229	(6.31, 38.69, 38.19)
2:216914012	rs552081322	A>T	D:230	(9.84, 39.82, 36.13)
2:216914005		R>Q	D:232	(11.76, 42.46, 32.23)
2:216913987		E>G	D:238	(11.06, 38.44, 24.73)
2:216908723		C>G	D:244	(8.61, 31.56, 14.62)
2:216908710		S>F	D:248	(7.81, 25.71, 12.82)
2:216908704	rs372956838	A>E	D:250	(8.86, 22.27, 15.76)
2:216908690		T>A	D:255	(-3.17, 22.48, 17.48)
2:216908680		S>L	D:258	(-2.16, 29.80, 24.16)
2:216908674	rs142596345	D>G	D:260	(0.58, 33.75, 28.07)
2:216908659		R>Q	D:265	(0.43, 41.38, 33.54)
2:216908660	rs190770435	R>W	D:265	(0.43, 41.38, 33.54)
2:216908657	rs137883002	S>G	D:266	(-2.00, 36.69, 34.12)
2:216908650	rs533394186	Y>C	D:268	(1.36, 39.39, 40.53)
2:216908648		T>A	D:269	(-3.09, 37.73, 42.16)
2:216908645	rs562985451	H>N	D:270	(-3.76, 42.28, 44.10)
2:216908641	rs149798403	S>W	D:271	(-3.03, 37.48, 47.10)
2:216908638		Y>C	D:272	(2.65, 36.61, 46.49)
2:216908630	rs150385654	P>S	D:275	(9.84, 41.11, 45.56)
2:216904069	COSM1663446	P>S	D:281	(16.00, 36.23, 32.64)
2:216904065		K>T	D:282	(18.35, 37.96, 29.42)
2:216904063	rs375539601	G>R	D:283	(17.39, 37.33, 25.71)
2:216904041	rs112838598	V>A	D:290	(13.29, 48.17, 29.64)
2:216904035		K>R	D:292	(15.96, 52.81, 31.88)
2:216904019	rs9288513	F>L	D:297	(9.37, 54.16, 39.11)
2:216904020		F>S	D:297	(9.37, 54.16, 39.11)