General Structure Information
| PDB ID | 3ld6 |
| HGNC Gene Label(s) | CYP51A1 |
| Structure Name | crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole |
| Resolution | 2.8Å |
| Reference | AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 445 |
| Number Of SNVs | 87 |
| Number Of Permutations | 16233 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.248 |
| p-value | 0.628 |
COSMIC
| Number Of Residues | 445 |
| Number Of SNVs | 6 |
| Number Of Permutations | 594 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.2 |
| p-value | 0.531 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 87 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.084 |
| p-value | 0.878 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
