Assessment of Structural Intolerance and Durability
General Structure Information 2p02 MAT2A crystal structure of the alpha subunit of human s- adenosylmethionine synthetase 2 1.21Å AUTH E.PAPAGRIGORIOU,N.SHAFQAT,A.ROJKOVA,F.H.NIESSEN,AUTH 2 K.L.KAVANAGH,F.VON DELFT,F.GORREC,E.UGOCHUKWU,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 4 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMANTITL 2 S-ADENOSYLMETHIONINE SYNTHETASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dfd MDH2 crystal structure of human malate dehydrogenase type 2 1.9Å AUTH E.UGOCHUKWU,N.SHAFQAT,A.ROJKOVA,M.SUNDSTROM,C.ARROWSMITH,AUTH 2 J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN MALATE DEHYDROGENASE TYPE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ea3 OPRL1 structure of the n/ofq opioid receptor in complex with a peptide mimetic 3.01Å AUTH A.A.THOMPSON,W.LIU,E.CHUN,V.KATRITCH,H.WU,E.VARDY,X.P.HUANG,AUTH 2 C.TRAPELLA,R.GUERRINI,G.CALO,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE NOCICEPTIN/ORPHANIN FQ RECEPTOR IN COMPLEXTITL 2 WITH A PEPTIDE MIMETIC.REF NATURE V. 485 395 2012REFN ISSN 0028-0836PMID 22596163DOI 10.1038/NATURE11085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ed7 DCC solution structure of the first fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ede DCC solution structure of the sixth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,M.YONEYAMA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SIXTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 2edb DCC solution structure of the fourth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rze HRH1 structure of the human histamine h1 receptor in complex with doxepin 3.1Å AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2lxu HNRNPH1 solution nmr structure of the eukaryotic rna recognition motif, rrm1, from the heterogeneous nuclear ribonucleoprotein h from homo sapiens, northeast structural genomics consortium (nesg) target hr8614a -1.0Å AUTH T.A.RAMELOT,Y.YANG,K.PEDERSON,R.SHASTRY,E.KOHAN,H.JANJUA,AUTH 2 R.XIAO,T.B.ACTON,J.K.EVERETT,J.H.PRESTEGARD,G.T.MONTELIONE,AUTH 3 M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF THE EUKARYOTIC RNA RECOGNITIONTITL 2 MOTIF, RRM1, FROM THE HETEROGENEOUS NUCLEARTITL 3 RIBONUCLEOPROTEIN […]
General Structure Information 2jrz KDM5C solution structure of the bright/arid domain from the human jarid1c protein. -1.0Å AUTH C.KOEHLER,S.BISHOP,E.F.DOWLER,P.SCHMIEDER,A.DIEHL,AUTH 2 H.OSCHKINAT,L.J.BALLTITL BACKBONE AND SIDECHAIN 1H, 13C AND 15N RESONANCETITL 2 ASSIGNMENTS OF THE BRIGHT/ARID DOMAIN FROM THETITL 3 HUMAN JARID1C (SMCX) PROTEIN.REF BIOMOL.NMR ASSIGN. V. 2 9 2008REFN ISSN 1874-2718PMID 19636912DOI 10.1007/S12104-007-9071-7 Variant Set Distributions […]