Assessment of Structural Intolerance and Durability
General Structure Information 4ib4 HTR2B crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine 2.7Å AUTH D.WACKER,C.WANG,V.KATRITCH,G.W.HAN,X.P.HUANG,E.VARDY,AUTH 2 J.D.MCCORVY,Y.JIANG,M.CHU,F.Y.SIU,W.LIU,H.E.XU,V.CHEREZOV,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL FEATURES FOR FUNCTIONAL SELECTIVITY AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 615 2013REFN ISSN 0036-8075PMID 23519215DOI 10.1126/SCIENCE.1232808 Variant Set Distributions Mapped Variants
General Structure Information 3ou5 SHMT2 human mitochondrial serine hydroxymethyltransferase 2 2.04Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL SERINETITL 2 HYDROXYMETHYLTRANSFERASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ed9 DCC solution structure of the third fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cog CTH crystal structure of human cystathionase (cystathionine gamma lyase) in complex with dl-propargylglycine 2.0Å AUTH Q.SUN,R.COLLINS,S.HUANG,L.HOLMBERG-SCHIAVONE,G.S.ANAND,AUTH 2 C.H.TAN,S.VAN-DEN-BERG,L.W.DENG,P.K.MOORE,T.KARLBERG,AUTH 3 J.SIVARAMANTITL STRUCTURAL BASIS FOR THE INHIBITION MECHANISM OF HUMANTITL 2 CYSTATHIONINE GAMMA-LYASE, AN ENZYME RESPONSIBLE FOR THETITL 3 PRODUCTION OF H(2)S.REF J.BIOL.CHEM. V. 284 3076 2009REFN ISSN 0021-9258PMID 19019829DOI 10.1074/JBC.M805459200 Variant Set […]
General Structure Information 2yvq CPS1 crystal structure of mgs domain of carbamoyl-phosphate synthetase from homo sapiens 1.98Å AUTH Y.XIE,IHSANAWATI,S.KISHISHITA,K.MURAYAMA,AUTH 2 C.TAKEMOTO,M.SHIROZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF MGS DOMAIN OFTITL 2 CARBAMOYL-PHOSPHATE SYNTHETASE FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dks CEACAM8 solution structure of the first ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8 -1.0Å AUTH K.NAGASHIMA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAIN OFTITL 2 HUMAN CARCINOEMBRYONIC ANTIGEN RELATED CELLTITL 3 ADHESION MOLECULE 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dao ETV6 solution structure of ets domain transcriptional factor etv6 protein -1.0Å AUTH T.N.NIRAULA,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF ETS DOMAIN TRANSCRIPTIONALTITL 2 FACTOR ETV6 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1v89 ARHGAP25 solution structure of the pleckstrin homology domain of human kiaa0053 protein -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,H.HIROTA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF HUMAN KIAA0053 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2edd DCC solution structure of the fifth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants