Assessment of Structural Intolerance and Durability
General Structure Information 3lmk GRM5 ligand binding domain of metabotropoc glutamate receptor mglur5 complexed with glutamate 2.44Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITHTITL 2 GLUTAMATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1h8b ACTN2 ef-hands 3,4 from alpha-actinin / z-repeat 7 from titin -1.0Å AUTH R.A.ATKINSON,C.JOSEPH,G.KELLY,F.W.MUSKETT,AUTH 2 T.A.FRENKIEL,D.NIETLISPACH,A.PASTORETITL CA2+-INDEPENDENT BINDING OF AN EF-HAND DOMAIN TO ATITL 2 NOVEL MOTIF IN THE ALPHA-ACTININ-TITIN COMPLEXREF NAT.STRUCT.BIOL. V. 8 853 2001REFN ISSN 1072-8368PMID 11573089DOI 10.1038/NSB1001-853 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2dm0 TXK solution structure of the sh2 domain of human tyrosine- protein kinase txk -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE TXKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ytq CRYBB2 structure of native human beta b2 crystallin 1.7Å AUTH M.A.SMITH,O.A.BATEMAN,R.JAENICKE,C.SLINGSBYTITL MUTATION OF INTERFACES IN DOMAIN-SWAPPED HUMANTITL 2 BETAB2-CRYSTALLINREF PROTEIN SCI. V. 16 615 2007REFN ISSN 0961-8368PMID 17327390DOI 10.1110/PS.062659107 Variant Set Distributions Mapped Variants
General Structure Information 3pbl DRD3 structure of the human dopamine d3 receptor in complex with eticlopride 2.89Å AUTH E.Y.CHIEN,W.LIU,Q.ZHAO,V.KATRITCH,G.W.HAN,M.A.HANSON,L.SHI,AUTH 2 A.H.NEWMAN,J.A.JAVITCH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE HUMAN DOPAMINE D3 RECEPTOR IN COMPLEX WITHTITL 2 A D2/D3 SELECTIVE ANTAGONIST.REF SCIENCE V. 330 1091 2010REFN ISSN 0036-8075PMID 21097933DOI 10.1126/SCIENCE.1197410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1wym TAGLN2 solution structure of the ch domain of human transgelin-2 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 TRANSGELIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n6h OPRD1 1.8 a structure of the human delta opioid 7tm receptor (psi community target) 1.8Å AUTH G.FENALTI,P.M.GIGUERE,V.KATRITCH,X.P.HUANG,A.A.THOMPSON,AUTH 2 V.CHEREZOV,B.L.ROTH,R.C.STEVENSTITL MOLECULAR CONTROL OF DELTA-OPIOID RECEPTOR SIGNALLING.REF NATURE V. 506 191 2014REFN ISSN 0028-0836PMID 24413399DOI 10.1038/NATURE12944 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d8n RCVRN crystal structure of human recoverin at 2.2 a resolution 2.2Å AUTH S.KAMO,S.KISHISHITA,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN RECOVERIN AT 2.2 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants