General Structure Information
| PDB ID | 3cog |
| HGNC Gene Label(s) | CTH |
| Structure Name | crystal structure of human cystathionase (cystathionine gamma lyase) in complex with dl-propargylglycine |
| Resolution | 2.0Å |
| Reference | AUTH Q.SUN,R.COLLINS,S.HUANG,L.HOLMBERG-SCHIAVONE,G.S.ANAND,AUTH 2 C.H.TAN,S.VAN-DEN-BERG,L.W.DENG,P.K.MOORE,T.KARLBERG,AUTH 3 J.SIVARAMANTITL STRUCTURAL BASIS FOR THE INHIBITION MECHANISM OF HUMANTITL 2 CYSTATHIONINE GAMMA-LYASE, AN ENZYME RESPONSIBLE FOR THETITL 3 PRODUCTION OF H(2)S.REF J.BIOL.CHEM. V. 284 3076 2009REFN ISSN 0021-9258PMID 19019829DOI 10.1074/JBC.M805459200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 373 |
| Number Of SNVs | 92 |
| Number Of Permutations | 28306 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.201 |
| p-value | 0.191 |
COSMIC
| Number Of Residues | 373 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 92 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.263 |
| p-value | 0.554 |