Assessment of Structural Intolerance and Durability
General Structure Information 2xyn ABL2 human abl2 in complex with aurora kinase inhibitor vx-680 2.81Å AUTH E.SALAH,E.UGOCHUKWU,A.J.BARR,F.VON DELFT,S.KNAPP,AUTH 2 J.M.ELKINSTITL CRYSTAL STRUCTURES OF ABL-RELATED GENE (ABL2) INTITL 2 COMPLEX WITH IMATINIB, TOZASERTIB (VX-680), AND ATITL 3 TYPE I INHIBITOR OF THE TRIAZOLE CARBOTHIOAMIDETITL 4 CLASS.REF J.MED.CHEM. V. 54 2359 2011REFN ISSN 0022-2623PMID 21417343DOI 10.1021/JM101506N Variant […]
General Structure Information 3fdt CBX5 crystal structure of the complex of human chromobox homolog 5 (cbx5) with h3k9(me)3 peptide 2.0Å AUTH L.KAUSTOV,H.OUYANG,M.AMAYA,A.LEMAK,N.NADY,S.DUAN,G.A.WASNEY,AUTH 2 Z.LI,M.VEDADI,M.SCHAPIRA,J.MIN,C.H.ARROWSMITHTITL RECOGNITION AND SPECIFICITY DETERMINANTS OF THE HUMAN CBXTITL 2 CHROMODOMAINS.REF J.BIOL.CHEM. V. 286 521 2011REFN ISSN 0021-9258PMID 21047797DOI 10.1074/JBC.M110.191411 Variant Set Distributions Mapped Variants
General Structure Information 2i3c ASPA crystal structure of an aspartoacylase from homo sapiens 2.8Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,J.G.MCCOY,AUTH 2 G.N.PHILLIPSTITL STRUCTURE OF ASPARTOACYLASE, THE BRAIN ENZYMETITL 2 IMPAIRED IN CANAVAN DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 104 456 2007REFN ISSN 0027-8424PMID 17194761DOI 10.1073/PNAS.0607817104 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lni STIP1 solution nmr structure of stress-induced-phosphoprotein 1 sti1 from homo sapiens, northeast structural genomics consortium target hr4403e -1.0Å AUTH Y.TANG,G.LIU,K.HAMILTON,C.CICCOSANTI,R.SHASTRY,B.ROST,AUTH 2 T.B.ACTON,R.XIAO,J.K.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4403EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iu2 NMT1 crystal structure of human type-i n-myristoyltransferase with bound myristoyl-coa and inhibitor ddd90096 1.73Å AUTH W.QIU,A.HUTCHINSON,A.WERNIMONT,Y.-H.LIN,A.KANIA,AUTH 2 M.RAVICHANDRAN,I.KOZIERADZKI,D.COSSAR,M.SCHAPIRA,AUTH 3 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.M.EDWARDS,P.G.WYATT,AUTH 4 M.A.J.FERGUSON,J.A.FREARSON,S.Y.BRAND,D.A.ROBINSON,AUTH 5 A.BOCHKAREV,R.HUITITL CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASETITL 2 WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD90096REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2bq0 YWHAB 14-3-3 protein beta (human) 2.5Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,AUTH 2 C.V.ROBINSON,J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,AUTH 3 J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONSTITL 2 IN THE 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dbg MNDA solution structure of the pyrin (paad-dapin) domain in human myeloid cell nuclear differentiation antigen -1.0Å AUTH K.SAITO,M.INOUE,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PYRIN (PAAD-DAPIN)TITL 2 DOMAIN IN HUMAN MYELOID CELL NUCLEARTITL 3 DIFFERENTIATION ANTIGENREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4djh OPRK1 structure of the human kappa opioid receptor in complex with jdtic 2.9Å AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rgz HMOX2 ensemble refinement of the protein crystal structure of human heme oxygenase-2 c127a (ho-2) with bound heme 2.61Å AUTH C.M.BIANCHETTI,L.YI,S.W.RAGSDALE,G.N.PHILLIPS JR.TITL COMPARISON OF APO- AND HEME-BOUND CRYSTAL STRUCTURES OF ATITL 2 TRUNCATED HUMAN HEME OXYGENASE-2.REF J.BIOL.CHEM. V. 282 37624 2007REFN ISSN 0021-9258PMID 17965015DOI 10.1074/JBC.M707396200 Variant Set Distributions Mapped Variants
General Structure Information 1x6g MATK solution structures of the sh3 domain of human megakaryocyte-associated tyrosine-protein kinase. -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMANTITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants