Assessment of Structural Intolerance and Durability
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 2bt2 RGS16 structure of the regulator of g-protein signaling 16 1.9Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA- SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2vpd BCL9 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 3ol2 PLXNB1 receptor-ligand structure of human semaphorin 4d with plexin b1. 2.99Å AUTH B.J.JANSSEN,R.A.ROBINSON,F.PEREZ-BRANGULI,C.H.BELL,AUTH 2 K.J.MITCHELL,C.SIEBOLD,E.Y.JONESTITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN SIGNALLING.REF NATURE V. 467 1118 2010REFN ISSN 0028-0836PMID 20877282DOI 10.1038/NATURE09468 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3sl9 BCL9 x-ray structure of beta catenin in complex with bcl9 2.2Å AUTH M.DE LA ROCHE,T.J.RUTHERFORD,D.GUPTA,D.B.VEPRINTSEV,B.SAXTY,AUTH 2 S.M.FREUND,M.BIENZTITL AN INTRINSICALLY LABILE ALPHA-HELIX ABUTTING THETITL 2 BCL9-BINDING SITE OF BETA-CATENIN IS REQUIRED FOR ITSTITL 3 INHIBITION BY CARNOSIC ACID.REF NAT COMMUN V. 3 680 2012REFN ESSN 2041-1723PMID 22353711DOI 10.1038/NCOMMS1680 Variant Set Distributions Mapped […]
General Structure Information 2gto FYB oxidized form of adap hsh3-n -1.0Å AUTH J.ZIMMERMANN,R.KUHNE,M.SYLVESTER,C.FREUNDTITL REDOX-REGULATED CONFORMATIONAL CHANGES IN AN SH3TITL 2 DOMAINREF BIOCHEMISTRY V. 46 6971 2007REFN ISSN 0006-2960PMID 17511475DOI 10.1021/BI700437R Variant Set Distributions Mapped Variants
General Structure Information 3t06 ARHGEF11 crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa 2.84Å AUTH J.A.BIELNICKI,A.V.SHKUMATOV,U.DEREWENDA,A.V.SOMLYO,AUTH 2 D.I.SVERGUN,Z.S.DEREWENDATITL INSIGHTS INTO THE MOLECULAR ACTIVATION MECHANISM OF THETITL 2 RHOA-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR, PDZRHOGEF.REF J.BIOL.CHEM. V. 286 35163 2011REFN ISSN 0021-9258PMID 21816819DOI 10.1074/JBC.M111.270918 Variant Set Distributions Ripley’s […]
General Structure Information 2vif SOCS6 crystal structure of socs6 sh2 domain in complex with a c-kit phosphopeptide 1.45Å AUTH F.ZADJALI,A.C.W.PIKE,M.VESTERLUND,J.SUN,C.WU,S.S.LI,AUTH 2 L.RONNSTRAND,S.KNAPP,A.BULLOCK,A.FLORES-MORALESTITL STRUCTURAL BASIS FOR C-KIT INHIBITION BY THETITL 2 SUPPRESSOR OF CYTOKINE SIGNALING 6 (SOCS6)TITL 3 UBIQUITIN LIGASE.REF J.BIOL.CHEM. V. 286 480 2011REFN ISSN 0021-9258PMID 21030588DOI 10.1074/JBC.M110.173526 Variant Set Distributions Mapped Variants
General Structure Information 4avx HGS hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution 1.68Å AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 […]
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants