Assessment of Structural Intolerance and Durability
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qbx EPHB2 ephb2/snew antagonistic peptide complex 2.3Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,G.NICOLA,L.K.DAVIS,AUTH 2 R.ABAGYAN,H.WIDMER,E.B.PASQUALE,P.KUHNTITL THREE-DIMENSIONAL STRUCTURE OF THE EPHB2 RECEPTORTITL 2 IN COMPLEX WITH AN ANTAGONISTIC PEPTIDE REVEALS ATITL 3 NOVEL MODE OF INHIBITION.REF J.BIOL.CHEM. V. 282 36505 2007REFN ISSN 0021-9258PMID 17897949DOI 10.1074/JBC.M706340200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e8n EPHA2 solution structure of the c-terminal sam-domain of ephaa2: ephrin type-a receptor 2 precursor (ec 2.7.10.1) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL SAM-DOMAIN OFTITL 2 EPHAA2: EPHRIN TYPE-A RECEPTOR 2 PRECURSOR (ECTITL 3 2.7.10.1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4iar HTR1B crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) 2.7Å AUTH C.WANG,Y.JIANG,J.MA,H.WU,D.WACKER,V.KATRITCH,G.W.HAN,W.LIU,AUTH 2 X.P.HUANG,E.VARDY,J.D.MCCORVY,X.GAO,X.E.ZHOU,K.MELCHER,AUTH 3 C.ZHANG,F.BAI,H.YANG,L.YANG,H.JIANG,B.L.ROTH,V.CHEREZOV,AUTH 4 R.C.STEVENS,H.E.XUTITL STRUCTURAL BASIS FOR MOLECULAR RECOGNITION AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 610 2013REFN ISSN 0036-8075PMID 23519210DOI 10.1126/SCIENCE.1232807 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3vw7 F2R crystal structure of human protease-activated receptor 1 (par1) bound with antagonist vorapaxar at 2.2 angstrom 2.2Å AUTH C.ZHANG,Y.SRINIVASAN,D.H.ARLOW,J.J.FUNG,D.PALMER,Y.ZHENG,AUTH 2 H.F.GREEN,A.PANDEY,R.O.DROR,D.E.SHAW,W.I.WEIS,S.R.COUGHLIN,AUTH 3 B.K.KOBILKATITL HIGH-RESOLUTION CRYSTAL STRUCTURE OF HUMANTITL 2 PROTEASE-ACTIVATED RECEPTOR 1REF NATURE V. 492 387 2012REFN ISSN 0028-0836PMID 23222541DOI 10.1038/NATURE11701 Variant Set Distributions Mapped Variants
General Structure Information 2npp PPP2R1A structure of the protein phosphatase 2a holoenzyme 3.3Å AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYMEREF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k1l EPHA1 nmr structures of dimeric transmembrane domain of the receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 -1.0Å AUTH E.V.BOCHAROV,M.L.MAYZEL,P.E.VOLYNSKY,M.V.GONCHARUK,AUTH 2 Y.S.ERMOLYUK,A.A.SCHULGA,E.O.ARTEMENKO,R.G.EFREMOV,AUTH 3 A.S.ARSENIEVTITL SPATIAL STRUCTURE AND PH-DEPENDENT CONFORMATIONALTITL 2 DIVERSITY OF DIMERIC TRANSMEMBRANE DOMAIN OF THETITL 3 RECEPTOR TYROSINE KINASE EPHA1.REF J.BIOL.CHEM. V. 283 29385 2008REFN ISSN 0021-9258PMID […]
General Structure Information 2koe CNR1 human cannabinoid receptor 1 – helix 7/8 peptide -1.0Å AUTH S.TYUKHTENKO,E.K.TIBURU,L.DESHMUKH,O.VINOGRADOVA,AUTH 2 D.R.JANERO,A.MAKRIYANNISTITL NMR SOLUTION STRUCTURE OF HUMAN CANNABINOIDTITL 2 RECEPTOR-1 HELIX 7/8 PEPTIDE: CANDIDATETITL 3 ELECTROSTATIC INTERACTIONS AND MICRODOMAINTITL 4 FORMATION.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 390 441 2009REFN ISSN 0006-291XPMID 19766594DOI 10.1016/J.BBRC.2009.09.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3cxl CHN1 crystal structure of human chimerin 1 (chn1) 2.6Å AUTH L.SHEN,M.BUCK,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants