General Structure Information
| PDB ID | 2npp |
| HGNC Gene Label(s) | PPP2R1A |
| Structure Name | structure of the protein phosphatase 2a holoenzyme |
| Resolution | 3.3Å |
| Reference | AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYMEREF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 582 |
| Number Of SNVs | 60 |
| Number Of Permutations | 37831 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.165 |
COSMIC
| Number Of Residues | 582 |
| Number Of SNVs | 16 |
| Number Of Permutations | 13984 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.092 |
| p-value | 0.008 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 15 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.12 |
| p-value | 0.002 |