Assessment of Structural Intolerance and Durability
General Structure Information 2f7s RAB27B the crystal structure of human rab27b bound to gdp 2.7Å AUTH J.WANG,S.ISMAIL,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL THE CRYSTAL STRUCTURE OF HUMAN RAB27BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fim TULP1 structure of the c-terminal domain of human tubby-like protein 1 1.9Å AUTH C.PERSSON,D.OGG,A.G.THORSELL,C.ARROWSMITH,H.BERGLUND,AUTH 2 A.EDWARDS,M.EHN,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,M.HOGBOM,AUTH 3 L.HOLMBERG-SCHIAVONE,T.KOTENYOVA,P.KURSULA,P.NILSSON-EHLE,AUTH 4 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 5 S.VAN DEN BERG,J.WEIGELT,B.M.HALLBERGTITL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKETITL 2 PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ihb RGS10 crystal structure of the heterodimeric complex of human rgs10 and activated gi alpha 3 2.71Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 4gul PIR study on structure and function relationships in human ferric pirin 1.8Å AUTH F.LIU,I.REHMANI,S.ESAKI,R.FU,L.CHEN,V.DE SERRANO,A.LIUTITL PIRIN IS AN IRON-DEPENDENT REDOX REGULATOR OF NF-KAPPA B.REF PROC.NATL.ACAD.SCI.USA V. 110 9722 2013REFN ISSN 0027-8424PMID 23716661DOI 10.1073/PNAS.1221743110 Variant Set Distributions Mapped Variants
General Structure Information 2dls ARHGEF11 solution structure of the pdz domain of human rho guanine nucleotide exchange factor 11 -1.0Å AUTH K.INOUE,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOTITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qqm NRP1 crystal structure of the a2b1b2 domains from human neuropilin-1 2.0Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4e71 PLXNB2 crystal structure of the rho gtpase binding domain of plexin b2 2.26Å AUTH X.GUAN,H.WANG,W.TEMPEL,Y.TONG,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ebz RGS12 solution structure of the rgs domain from human regulator of g-protein signaling 12 (rgs12) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 12 (RGS12)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wjm SPTBN2 solution structure of pleckstrin homology domain of human beta iii spectrin. -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PLECKSTRIN HOMOLOGY DOMAINTITL 2 OF HUMAN BETA III SPECTRINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ri9 FYB structure of a helically extended sh3 domain of the t cell adapter protein adap -1.0Å AUTH K.HEUER,M.KOFLER,G.LANGDON,K.THIEMKE,C.FREUNDTITL STRUCTURE OF A HELICALLY EXTENDED SH3 DOMAIN OFTITL 2 THE T CELL ADAPTER PROTEIN ADAP.REF STRUCTURE V. 12 603 2004REFN ISSN 0969-2126PMID 15062083DOI 10.1016/J.STR.2004.02.021 Variant Set Distributions Mapped Variants