Assessment of Structural Intolerance and Durability
General Structure Information 3dlm SETDB1 crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1 1.77Å AUTH L.DOMBROVSKI,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF TUDOR DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2oo1 BRD3 crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (brd3) 1.7Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1v05 FLNC dimerization of human filamin c: crystal structure of the domain 24 1.43Å AUTH R.PUDAS,T.-R.KIEMA,P.J.G.BUTLER,M.STEWART,J.YLANNETITL STRUCTURAL BASIS FOR VERTEBRATE FILAMINTITL 2 DIMERIZATIONREF STRUCTURE V. 13 111 2005REFN ISSN 0969-2126PMID 15642266DOI 10.1016/J.STR.2004.10.014 Variant Set Distributions Mapped Variants
General Structure Information 2jzx PCBP2 pcbp2 kh1-kh2 domains -1.0Å AUTH Z.DU,S.FENN,R.TJHEN,T.JAMESTITL STRUCTURE OF THE FIRST AND SECOND KH DOMAINS OF HUMAN POLY-CTITL 2 BINDING PROTEIN-2 REVEALS INSIGHTS INTO ITS REGULATORYTITL 3 MECHANISMSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ujy ARHGEF6 solution structure of sh3 domain in rac/cdc42 guanine nucleotide exchange factor(gef) 6 -1.0Å AUTH F.HE,Y.MUTO,H.UDA,S.KOSHIBA,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAGAYAMA,AUTH 5 S.YOKOYAMATITL SOLUTION STRUCTURE OF SH3 DOMAIN IN RAC/CDC42TITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR(GEF) 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ux0 CAMK2G structure of the oligomerisation domain of calcium- calmodulin dependent protein kinase ii gamma 2.46Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 4i6x PDIA5 crystal structure of non-catalyic domain of protein disulfide isomerase-related (pdir) protein 1.5Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL STRUCTURE OF THE NON-CATALYTIC DOMAIN OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN (PDIR) REVEALS FUNCTIONTITL 3 IN PROTEIN BINDING.REF PLOS ONE V. 8 62021 2013REFN ESSN 1932-6203PMID 23614004DOI 10.1371/JOURNAL.PONE.0062021 Variant Set Distributions Mapped Variants
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3oxq CACNA1C crystal structure of ca2+/cam-cav1.2 pre-iq/iq domain complex 2.55Å AUTH E.Y.KIM,C.H.RUMPF,F.VAN PETEGEM,R.J.ARANT,F.FINDEISEN,AUTH 2 E.S.COOLEY,E.Y.ISACOFF,D.L.MINORTITL MULTIPLE C-TERMINAL TAIL CA(2+)/CAMS REGULATE CA(V)1.2TITL 2 FUNCTION BUT DO NOT MEDIATE CHANNEL DIMERIZATION.REF EMBO J. V. 29 3924 2010REFN ISSN 0261-4189PMID 20953164DOI 10.1038/EMBOJ.2010.260 Variant Set Distributions Mapped Variants
General Structure Information 1xv9 NR1I3 crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione. 2.7Å AUTH R.X.XU,M.H.LAMBERT,B.B.WISELY,E.N.WARREN,AUTH 2 E.E.WEINERT,G.M.WAITT,J.D.WILLIAMS,J.L.COLLINS,AUTH 3 L.B.MOORE,T.M.WILLSON,J.T.MOORETITL A STRUCTURAL BASIS FOR CONSTITUTIVE ACTIVITY INTITL 2 THE HUMAN CAR/RXRALPHA HETERODIMER.REF MOL.CELL V. 16 919 2004REFN ISSN 1097-2765PMID 15610735DOI 10.1016/J.MOLCEL.2004.11.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]