Assessment of Structural Intolerance and Durability
General Structure Information 1y7x MVP solution structure of a two-repeat fragment of major vault protein -1.0Å AUTH G.KOZLOV,O.VAVELYUK,O.MINAILIUC,D.BANVILLE,AUTH 2 K.GEHRING,I.EKIELTITL SOLUTION STRUCTURE OF A TWO-REPEAT FRAGMENT OFTITL 2 MAJOR VAULT PROTEIN.REF J.MOL.BIOL. V. 356 444 2006REFN ISSN 0022-2836PMID 16373071DOI 10.1016/J.JMB.2005.11.064 Variant Set Distributions Mapped Variants
General Structure Information 2k9u FLNC solution nmr structure of the filamin-migfilin complex -1.0Å AUTH S.S.ITHYCHANDA,M.DAS,Y.Q.MA,K.DING,X.WANG,S.GUPTA,C.WU,AUTH 2 E.F.PLOW,J.QINTITL MIGFILIN, A MOLECULAR SWITCH IN REGULATION OF INTEGRINTITL 2 ACTIVATION.REF J.BIOL.CHEM. V. 284 4713 2009REFN ISSN 0021-9258PMID 19074766DOI 10.1074/JBC.M807719200 Variant Set Distributions Mapped Variants
General Structure Information 3f31 SPTAN1 crystal structure of the n-terminal region of alphaii-spectrin tetramerization domain 2.3Å AUTH S.MEHBOOB,Y.SONG,M.WITEK,F.LONG,B.D.SANTARSIERO,AUTH 2 M.E.JOHNSON,L.W.FUNGTITL CRYSTAL STRUCTURE OF THE NONERYTHROID ALPHA-SPECTRINTITL 2 TETRAMERIZATION SITE REVEALS DIFFERENCES BETWEEN ERYTHROIDTITL 3 AND NONERYTHROID SPECTRIN TETRAMER FORMATION.REF J.BIOL.CHEM. V. 285 14572 2010REFN ISSN 0021-9258PMID 20228407DOI 10.1074/JBC.M109.080028 Variant Set Distributions Mapped Variants
General Structure Information 2k60 STIM1 nmr structure of calcium-loaded stim1 ef-sam -1.0Å AUTH P.B.STATHOPULOS,L.ZHENG,G.Y.LI,M.J.PLEVIN,M.IKURATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO STIM1-MEDIATEDTITL 2 INITIATION OF STORE-OPERATED CALCIUM ENTRY.REF CELL(CAMBRIDGE,MASS.) V. 135 110 2008REFN ISSN 0092-8674PMID 18854159DOI 10.1016/J.CELL.2008.08.006 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bor EIF4A2 crystal structure of the deadc domain of human translation initiation factor 4a-2 1.85Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3bhh CAMK2B crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b) 2.4Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,F.NIESEN,N.BURGESS,A.BULLOCK,AUTH 2 G.BERRIDGE,A.C.W.PIKE,E.UGOCHUKWU,E.S.PILKA,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE IIB ISOFORM 1 (CAMK2B).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cpn TARBP2 solution structure of the second dsrbd of tar rna-binding protein 2 -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND DSRBD OF TARTITL 2 RNA-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gxb SNX17 structure of the snx17 atypical ferm domain bound to the npxy motif of p-selectin 1.8Å AUTH R.GHAI,A.BUGARCIC,H.LIU,S.J.NORWOOD,S.SKELDAL,E.J.COULSON,AUTH 2 S.S.LI,R.D.TEASDALE,B.M.COLLINSTITL STRUCTURAL BASIS FOR ENDOSOMAL TRAFFICKING OF DIVERSETITL 2 TRANSMEMBRANE CARGOS BY PX-FERM PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 110 E643 2013REFN ISSN 0027-8424PMID 23382219DOI 10.1073/PNAS.1216229110 Variant Set Distributions Mapped Variants
General Structure Information 2ee1 CHD4 solution structures of the chromo domain of human chromodomain helicase-dna-binding protein 4 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE CHROMO DOMAIN OF HUMANTITL 2 CHROMODOMAIN HELICASE-DNA-BINDING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lb6 IL13RA2 the structure of il-13 in complex with il-13ralpha2 3.05Å AUTH P.J.LUPARDUS,M.E.BIRNBAUM,K.C.GARCIATITL MOLECULAR BASIS FOR SHARED CYTOKINE RECOGNITION REVEALED INTITL 2 THE STRUCTURE OF AN UNUSUALLY HIGH AFFINITY COMPLEX BETWEENTITL 3 IL-13 AND IL-13RALPHA2.REF STRUCTURE V. 18 332 2010REFN ISSN 0969-2126PMID 20223216DOI 10.1016/J.STR.2010.01.003 Variant Set Distributions Ripley’s K Analysis Plots Variant […]