Assessment of Structural Intolerance and Durability
General Structure Information 2emw ZNF268 solution structure of the c2h2 type zinc finger (region 301- 331) of human zinc finger protein 268 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 301-331) OF HUMAN ZINC FINGER PROTEIN 268REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4ddp BECN1 crystal structure of beclin 1 evolutionarily conserved domain(ecd) 1.55Å AUTH W.HUANG,W.CHOI,W.HU,N.MI,Q.GUO,M.MA,M.LIU,Y.TIAN,P.LU,AUTH 2 F.L.WANG,H.DENG,L.LIU,N.GAO,L.YU,Y.SHITITL CRYSTAL STRUCTURE AND BIOCHEMICAL ANALYSES REVEAL BECLIN 1TITL 2 AS A NOVEL MEMBRANE BINDING PROTEINREF CELL RES. 2012REFN ISSN 1001-0602PMID 22310240DOI 10.1038/CR.2012.24 Variant Set Distributions Mapped Variants
General Structure Information 3jue ACAP1 crystal structure of arfgap and ank repeat domain of acap1 2.3Å AUTH M.BAI,X.PANG,J.LOU,Q.ZHOU,K.ZHANG,J.MA,J.LI,F.SUN,V.W.HSUTITL MECHANISTIC INSIGHTS INTO REGULATED CARGO BINDING BY ACAP1TITL 2 PROTEINREF J.BIOL.CHEM. V. 287 28675 2012REFN ISSN 0021-9258PMID 22645133DOI 10.1074/JBC.M112.378810 Variant Set Distributions Mapped Variants
General Structure Information 1by1 ARHGEF7 dbl homology domain from beta-pix -1.0Å AUTH B.AGHAZADEH,K.ZHU,T.J.KUBISESKI,G.A.LIU,T.PAWSON,AUTH 2 Y.ZHENG,M.K.ROSENTITL STRUCTURE AND MUTAGENESIS OF THE DBL HOMOLOGYTITL 2 DOMAINREF NAT.STRUCT.BIOL. V. 5 1098 1998REFN ISSN 1072-8368PMID 9846881DOI 10.1038/4209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iez IQGAP2 crystal structure of the rasgap c-terminal (rgc) domain of iqgap2 1.5Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RASGAP C-TERMINAL (RGC)TITL 2 DOMAIN OF IQGAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2j4o TAB1 structure of tab1 2.25Å AUTH S.H.CONNER,G.KULAR,M.PEGGIE,S.SHEPHERD,AUTH 2 A.W.SCHUTTELKOPF,P.COHEN,D.M.F.VAN AALTENTITL TAK1-BINDING PROTEIN 1 IS A PSEUDOPHOSPHATASE.REF BIOCHEM.J. V. 399 427 2006REFN ISSN 0264-6021PMID 16879102DOI 10.1042/BJ20061077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1joc EEA1 eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate 2.2Å AUTH J.J.DUMAS,E.MERITHEW,E.SUDHARSHAN,D.RAJAMANI,AUTH 2 S.HAYES,D.LAWE,S.CORVERA,D.G.LAMBRIGHTTITL MULTIVALENT ENDOSOME TARGETING BY HOMODIMERIC EEA1.REF MOL.CELL V. 8 947 2001REFN ISSN 1097-2765PMID 11741531DOI 10.1016/S1097-2765(01)00385-9 Variant Set Distributions Mapped Variants
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants