Assessment of Structural Intolerance and Durability
General Structure Information 2d7m FLNC solution structure of the 14th filamin domain from human filamin c -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yuf NAB1 solution structure of the ncd2 domain in human transcriptional repressor nab1 protein -1.0Å AUTH K.SAITO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NCD2 DOMAIN IN HUMANTITL 2 TRANSCRIPTIONAL REPRESSOR NAB1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3teq STIM1 crystal structure of soar domain 1.9Å AUTH X.YANG,H.JIN,X.CAI,S.LI,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE ACTIVATION OFTITL 2 STROMAL INTERACTION MOLECULE 1 (STIM1).REF PROC.NATL.ACAD.SCI.USA V. 109 5657 2012REFN ISSN 0027-8424PMID 22451904DOI 10.1073/PNAS.1118947109 Variant Set Distributions Mapped Variants
General Structure Information 2qms GRB7 crystal structure of a signaling molecule 2.1Å AUTH C.J.PORTER,J.M.MATTHEWS,J.P.MACKAY,S.E.PURSGLOVE,AUTH 2 J.W.SCHMIDBERGER,P.J.LEEDMAN,S.C.PERO,D.N.KRAG,AUTH 3 M.C.WILCE,J.A.WILCETITL GRB7 SH2 DOMAIN STRUCTURE AND INTERACTIONS WITH ATITL 2 CYCLIC PEPTIDE INHIBITOR OF CANCER CELL MIGRATIONTITL 3 AND PROLIFERATION.REF BMC STRUCT.BIOL. V. 7 58 2007REFN ESSN 1472-6807PMID 17894853DOI 10.1186/1472-6807-7-58 Variant Set Distributions Mapped Variants
General Structure Information 4epu ANGPT1 ang1 fibrinogen-related domain (fred) 2.1Å AUTH C.C.YEYKAL,L.SUNDARESAN,M.MRKSICH,E.J.ADAMSTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE ANG1TITL 2 FIBRINOGEN-RELATED DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2i99 CRYM crystal structure of human mu_crystallin at 2.6 angstrom 2.6Å AUTH Z.CHENG,L.SUN,J.HE,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN {MICRO}-CRYSTALLIN COMPLEXED WITHTITL 2 NADPHREF PROTEIN SCI. V. 16 329 2007REFN ISSN 0961-8368PMID 17242435DOI 10.1110/PS.062556907 Variant Set Distributions Mapped Variants
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ku8 PRKG1 structures of pkgi reveal a cgmp-selective activation mechanism 1.99Å AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 Variant Set Distributions Mapped Variants
General Structure Information 1hzd AUH crystal structure of human auh protein, an rna-binding homologue of enoyl-coa hydratase 2.2Å AUTH K.KURIMOTO,S.FUKAI,O.NUREKI,Y.MUTO,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN AUH PROTEIN, ATITL 2 SINGLE-STRANDED RNA BINDING HOMOLOG OF ENOYL-COATITL 3 HYDRATASE.REF STRUCTURE V. 9 1253 2001REFN ISSN 0969-2126PMID 11738050DOI 10.1016/S0969-2126(01)00686-4 Variant Set Distributions Mapped Variants
General Structure Information 2yrp NFATC4 solution structure of the tig domain from human nuclear factor of activated t-cells, cytoplasmic 4 -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TIG DOMAIN FROM HUMANTITL 2 NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants