Assessment of Structural Intolerance and Durability
General Structure Information 2ct7 RNF31 solution structure of the ibr domain of the ring finger protein 31 protein -1.0Å AUTH K.MIYAMOTO,S.KOSHIBA,T.TOMIZAWA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IBR DOMAIN OF THE RINGTITL 2 FINGER PROTEIN 31 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dmf RNF25 an extended conformation of the rwd domain of human ring finger protein 25 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,S.WATABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL AN EXTENDED CONFORMATION OF THE RWD DOMAIN OFTITL 2 HUMAN RING FINGER PROTEIN 25REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qc3 RPE crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699) from homo sapiens at 2.20 a resolution 2.2Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A D-RIBULOSE-5-PHOSPHATE-3-EPIMERASETITL 2 (NP_954699) FROM HOMO SAPIENS AT 2.20 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3al2 TOPBP1 crystal structure of topbp1 brct7/8 2.0Å AUTH C.C.LEUNG,Z.GONG,J.CHEN,J.N.GLOVERTITL MOLECULAR BASIS OF BACH1/FANCJ RECOGNITION BY TOPBP1 IN DNATITL 2 REPLICATION CHECKPOINT CONTROLREF J.BIOL.CHEM. V. 286 4292 2011REFN ISSN 0021-9258PMID 21127055DOI 10.1074/JBC.M110.189555 Variant Set Distributions Mapped Variants
General Structure Information 4bx9 VPS33A human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ecn RNF141 solution structure of the ring domain of the human ring finger protein 141 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 RING FINGER PROTEIN 141REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4akv SNX33 crystal structure of human sorting nexin 33 (snx33) 2.65Å AUTH A.OBERHOLZER,D.S.FROESE,T.KROJER,L.SHRESTHA,AUTH 2 P.FILIPPAKOPOULOS,J.R.C.MUNIZ,F.VON DELFT,C.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,C.BOUNTRA,W.W.YUETITL STRUCTURE OF HUMAN SORTING NEXIN 33REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s8i DDI1 the retroviral-like protease (rvp) domain of human ddi1 1.7Å AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x4v ZFAND2B solution structure of the zf-an1 domain from human hypothetical protein loc130617 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-AN1 DOMAIN FROM HUMANTITL 2 HYPOTHETICAL PROTEIN LOC130617REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants