Assessment of Structural Intolerance and Durability
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 2gl7 CTNNB1 crystal structure of a beta-catenin/bcl9/tcf4 complex 2.6Å AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jod ADCYAP1R1 pac1-rshort n-terminal ec domain pacap(6-38) complex -1.0Å AUTH C.SUN,D.SONG,R.A.DAVIS-TABER,L.W.BARRETT,V.E.SCOTT,AUTH 2 P.L.RICHARDSON,A.PEREDA-LOPEZ,M.E.UCHIC,AUTH 3 L.R.SOLOMON,M.R.LAKE,K.A.WALTER,P.J.HAJDUK,AUTH 4 E.T.OLEJNICZAKTITL SOLUTION STRUCTURE AND MUTATIONAL ANALYSIS OFTITL 2 PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDETITL 3 BINDING TO THE EXTRACELLULAR DOMAIN OF PAC1-RS.REF PROC.NATL.ACAD.SCI.USA V. 104 7875 2007REFN ISSN 0027-8424PMID 17470806DOI 10.1073/PNAS.0611397104 Variant Set Distributions Mapped Variants
General Structure Information 2cp5 CLIP1 solution structure of the 1st cap-gly domain in human clip- 170/restin -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-170/RESTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lot APLNR ar55 solubilised in sds micelles -1.0Å AUTH D.N.LANGELAAN,J.K.RAINEYTITL AR55 SOLUBILISED IN SDS MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3us4 MATK crystal structure of a sh2 domain of a megakaryocyte-associated tyrosine kinase (matk) from homo sapiens at 1.50 a resolution 1.5Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A SH2 DOMAIN OF ATITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE KINASE (MATK) FROM HOMOTITL 3 SAPIENS […]
General Structure Information 2gwf USP8 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants
General Structure Information 2fs7 CRABP2 crystal structure of apo-cellular retinoic acid binding protein type ii at 1.55 angstroms resolution 1.55Å AUTH S.VAEZESLAMI,E.MATHES,C.VASILEIOU,B.BORHAN,AUTH 2 J.H.GEIGERTITL THE STRUCTURE OF APO-WILD-TYPE CELLULAR RETINOICTITL 2 ACID BINDING PROTEIN II AT 1.4 A AND ITSTITL 3 RELATIONSHIP TO LIGAND BINDING AND NUCLEARTITL 4 TRANSLOCATION.REF J.MOL.BIOL. V. 363 687 2006REFN ISSN […]
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 1l9l GNLY granulysin from human cytolytic t lymphocytes 0.92Å AUTH D.H.ANDERSON,M.R.SAWAYA,D.CASCIO,W.ERNST,R.MODLIN,AUTH 2 A.KRENSKY,D.EISENBERGTITL GRANULYSIN CRYSTAL STRUCTURE AND ATITL 2 STRUCTURE-DERIVED LYTIC MECHANISMREF J.MOL.BIOL. V. 325 355 2002REFN ISSN 0022-2836PMID 12488100DOI 10.1016/S0022-2836(02)01234-2 Variant Set Distributions Mapped Variants