Assessment of Structural Intolerance and Durability
General Structure Information 2dbg MNDA solution structure of the pyrin (paad-dapin) domain in human myeloid cell nuclear differentiation antigen -1.0Å AUTH K.SAITO,M.INOUE,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PYRIN (PAAD-DAPIN)TITL 2 DOMAIN IN HUMAN MYELOID CELL NUCLEARTITL 3 DIFFERENTIATION ANTIGENREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l27 CRHR1 nmr structure of the ecd1 of crf-r1 in complex with a peptide agonist -1.0Å AUTH C.R.GRACE,M.H.PERRIN,J.GULYAS,J.E.RIVIER,W.W.VALE,R.RIEKTITL NMR STRUCTURE OF THE FIRST EXTRACELLULAR DOMAIN OFTITL 2 CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (ECD1-CRF-R1)TITL 3 COMPLEXED WITH A HIGH AFFINITY AGONIST.REF J.BIOL.CHEM. V. 285 38580 2010REFN ISSN 0021-9258PMID 20843795DOI 10.1074/JBC.M110.121897 Variant Set Distributions Mapped […]
General Structure Information 4djh OPRK1 structure of the human kappa opioid receptor in complex with jdtic 2.9Å AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1jm7 BRCA1 solution structure of the brca1/bard1 ring-domain heterodimer -1.0Å AUTH P.S.BRZOVIC,P.RAJAGOPAL,D.W.HOYT,M.C.KING,AUTH 2 R.E.KLEVITTITL STRUCTURE OF A BRCA1-BARD1 HETERODIMERIC RING-RINGTITL 2 COMPLEX.REF NAT.STRUCT.BIOL. V. 8 833 2001REFN ISSN 1072-8368PMID 11573085DOI 10.1038/NSB1001-833 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rgz HMOX2 ensemble refinement of the protein crystal structure of human heme oxygenase-2 c127a (ho-2) with bound heme 2.61Å AUTH C.M.BIANCHETTI,L.YI,S.W.RAGSDALE,G.N.PHILLIPS JR.TITL COMPARISON OF APO- AND HEME-BOUND CRYSTAL STRUCTURES OF ATITL 2 TRUNCATED HUMAN HEME OXYGENASE-2.REF J.BIOL.CHEM. V. 282 37624 2007REFN ISSN 0021-9258PMID 17965015DOI 10.1074/JBC.M707396200 Variant Set Distributions Mapped Variants
General Structure Information 1x6g MATK solution structures of the sh3 domain of human megakaryocyte-associated tyrosine-protein kinase. -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMANTITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lce BCL6 chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium -1.0Å AUTH H.LEE,G.T.MONTELIONE,J.H.PRESTEGARDTITL SOLUTION STRUCTURE OF HR4436B.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e2u CLIP1 crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued) 2.6Å AUTH A.WEISBRICH,S.HONNAPPA,R.JAUSSI,O.OKHRIMENKO,D.FREY,AUTH 2 I.JELESAROV,A.AKHMANOVA,M.O.STEINMETZTITL STRUCTURE-FUNCTION RELATIONSHIP OF CAP-GLY DOMAINSREF NAT.STRUCT.MOL.BIOL. V. 14 959 2007REFN ISSN 1545-9993PMID 17828277DOI 10.1038/NSMB1291 Variant Set Distributions Mapped Variants
General Structure Information 2cp6 CLIP1 solution structure of the 2nd cap-gly domain in human clip- 170/restin -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-170/RESTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lly CHRNA4 nmr structures of the transmembrane domains of the nachr a4 subunit -1.0Å AUTH V.BONDARENKO,D.MOWREY,T.TILLMAN,T.CUI,L.T.LIU,Y.XU,P.TANGTITL NMR STRUCTURES OF THE TRANSMEMBRANE DOMAINS OF THE A4B2TITL 2 NACHR.REF BIOCHIM.BIOPHYS.ACTA V.1818 1261 2012REFN ISSN 0006-3002PMID 22361591DOI 10.1016/J.BBAMEM.2012.02.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants