Assessment of Structural Intolerance and Durability
General Structure Information 4fss RASA1 crystal structure of a ras p21 protein activator (rasa1) from homo sapiens at 2.25 a resolution 2.25Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A RAS P21 PROTEIN ACTIVATOR (RASA1)TITL 2 FROM HOMO SAPIENS AT 2.25 A RESOLUTIONREF TO BE PUBLISHEDREFN […]
General Structure Information 2uur COL9A1 n-terminal nc4 domain of collagen ix 1.8Å AUTH V.-M.LEPPANEN,H.TOSSAVAINEN,P.PERMI,L.LEHTIO,AUTH 2 G.RONNHOLM,A.GOLDMAN,I.KILPELAINEN,T.PIHLAJAMAATITL CRYSTAL STRUCTURE OF THE N-TERMINAL NC4 DOMAIN OFTITL 2 COLLAGEN IX, A ZINC BINDING MEMBER OF THE LAMININ-TITL 3 NEUREXIN-SEX HORMONE BINDING GLOBULIN (LNS) DOMAINTITL 4 FAMILY.REF J.BIOL.CHEM. V. 282 23219 2007REFN ISSN 0021-9258PMID 17553797DOI 10.1074/JBC.M702514200 Variant Set Distributions […]
General Structure Information 1m5i APC crystal structure of the coiled coil region 129-250 of the tumor suppressor gene product apc 2.0Å AUTH L.TICKENBROCK,J.CRAMER,I.R.VETTER,O.MULLERTITL THE COILED COIL REGION (AMINO ACIDS 129-250) OFTITL 2 THE TUMOR SUPPRESSOR PROTEIN ADENOMATOUS POLYPOSISTITL 3 COLI (APC). ITS STRUCTURE AND ITS INTERACTION WITHTITL 4 CHROMOSOME MAINTENANCE REGION 1 (CRM-1).REF J.BIOL.CHEM. V. […]
General Structure Information 3umn LMNB1 crystal structure of lamin-b1 2.0Å AUTH J.RUAN,C.XU,C.BIAN,R.LAM,J.P.WANG,J.KANIA,J.MIN,J.ZANGTITL CRYSTAL STRUCTURES OF THE COIL 2B FRAGMENT AND THE GLOBULARTITL 2 TAIL DOMAIN OF HUMAN LAMIN B1.REF FEBS LETT. V. 586 314 2012REFN ISSN 0014-5793PMID 22265972DOI 10.1016/J.FEBSLET.2012.01.007 Variant Set Distributions Mapped Variants
General Structure Information 1n3h SHC1 coupling of folding and binding in the ptb domain of the signaling protein shc -1.0Å AUTH A.FAROOQ,L.ZENG,K.S.YAN,K.S.RAVICHANDRAN,M.-M.ZHOUTITL COUPLING OF FOLDING AND BINDING IN THE PTB DOMAINTITL 2 OF THE SIGNALING PROTEIN SHCREF STRUCTURE V. 11 905 2003REFN ISSN 0969-2126PMID 12906822DOI 10.1016/S0969-2126(03)00134-5 Variant Set Distributions Mapped Variants
General Structure Information 2vph PTPN4 crystal structure of the human protein tyrosine phosphatase, non-receptor type 4, pdz domain 1.9Å AUTH A.K.ROOS,J.WANG,N.BURGESS-BROWN,J.M.ELKINS,K.KAVANAGH,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,F.VON DELFT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE, NON-RECEPTOR TYPE 4, PDZ DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1he3 BLVRB human biliverdin ix beta reductase: nadp/mesobiliverdin iv alpha ternary complex 1.4Å AUTH P.J.B.PEREIRA,S.MACEDO-RIBEIRO,A.PARRAGA,AUTH 2 R.PEREZ-LUQUE,O.CUNNINGHAM,K.DARCY,T.J.MANTLE,AUTH 3 M.COLLTITL STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE,TITL 2 AN EARLY FETAL BILIRUBIN IX PRODUCING ENZYMEREF NAT.STRUCT.BIOL. V. 8 215 2001REFN ISSN 1072-8368PMID 11224564DOI 10.1038/84948 Variant Set Distributions Mapped Variants
General Structure Information 2r53 BMP6 crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6) 2.1Å AUTH S.SAREMBA,J.NICKEL,A.SEHER,A.KOTZSCH,W.SEBALD,AUTH 2 T.D.MUELLERTITL TYPE I RECEPTOR BINDING OF BONE MORPHOGENETICTITL 2 PROTEIN 6 IS DEPENDENT ON N-GLYCOSYLATION OF THETITL 3 LIGAND.REF FEBS J. V. 275 172 2007REFN ISSN 1742-464XPMID 18070108DOI 10.1111/J.1742-4658.2007.06187.X Variant Set Distributions Mapped Variants
General Structure Information 1ggz CALML3 crystal structure of the calmodulin-like protein (hclp) from human epithelial cells 1.5Å AUTH B.G.HAN,M.HAN,H.SUI,P.YASWEN,P.J.WALIAN,B.K.JAPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-LIKETITL 2 PROTEIN: INSIGHTS INTO ITS FUNCTIONAL ROLE.REF FEBS LETT. V. 521 24 2002REFN ISSN 0014-5793PMID 12067719DOI 10.1016/S0014-5793(02)02780-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2hc2 PTPRB engineered protein tyrosine phosphatase beta catalytic domain 1.4Å AUTH A.G.EVDOKIMOV,M.POKROSS,R.WALTER,M.MEKEL,B.COX,AUTH 2 C.LI,R.BECHARD,F.GENBAUFFE,R.ANDREWS,C.DIVEN,AUTH 3 B.HOWARD,V.RASTOGI,J.GRAY,M.MAIER,K.G.PETERSTITL ENGINEERING THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 TYROSINE PHOSPHATASE BETA FOR STRUCTURE-BASED DRUGTITL 3 DISCOVERY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1435 2006REFN ISSN 0907-4449PMID 17139078DOI 10.1107/S0907444906037784 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]