General Structure Information
| PDB ID | 1m5i |
| HGNC Gene Label(s) | APC |
| Structure Name | crystal structure of the coiled coil region 129-250 of the tumor suppressor gene product apc |
| Resolution | 2.0Å |
| Reference | AUTH L.TICKENBROCK,J.CRAMER,I.R.VETTER,O.MULLERTITL THE COILED COIL REGION (AMINO ACIDS 129-250) OFTITL 2 THE TUMOR SUPPRESSOR PROTEIN ADENOMATOUS POLYPOSISTITL 3 COLI (APC). ITS STRUCTURE AND ITS INTERACTION WITHTITL 4 CHROMOSOME MAINTENANCE REGION 1 (CRM-1).REF J.BIOL.CHEM. V. 277 32332 2002REFN ISSN 0021-9258PMID 12070164DOI 10.1074/JBC.M203990200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 105 |
| Number Of SNVs | 25 |
| Number Of Permutations | 7602 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.55 |
| p-value | 0.037 |
COSMIC
| Number Of Residues | 105 |
| Number Of SNVs | 4 |
| Number Of Permutations | 854 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.167 |
| p-value | 0.422 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 25 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | -0.483 |
| p-value | 0.041 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
