Assessment of Structural Intolerance and Durability
General Structure Information 3fbk RGS3 crystal structure of the c2 domain of the human regulator of g-protein signaling 3 isoform 6 (rgp3), northeast structural genomics consortium target hr5550a 2.0Å AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,L.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,E.L.FOOTE,R.SHASTRY,J.K.EVERETT,AUTH 3 R.NAIR,T.B.ACTON,B.ROST,G.T.MONTELIONE,J.F.HUNT,AUTH 4 L.TONGTITL CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 3 ISOFORM 6TITL 3 […]
General Structure Information 3p0u NR2C2 crystal structure of the ligand binding domain of human testicular receptor 4 3.0Å AUTH X.E.ZHOU,K.M.SUINO-POWELL,Y.XU,C.W.CHAN,O.TANABE,S.W.KRUSE,AUTH 2 R.REYNOLDS,J.D.ENGEL,H.E.XUTITL THE ORPHAN NUCLEAR RECEPTOR TR4 IS A VITAMIN A-ACTIVATEDTITL 2 NUCLEAR RECEPTOR.REF J.BIOL.CHEM. V. 286 2877 2011REFN ISSN 0021-9258PMID 21068381DOI 10.1074/JBC.M110.168740 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ebv NUP153 solution structure of the third zf-ranbp domain from human nuclear pore complex protein nup153 -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD ZF-RANBP DOMAINTITL 2 FROM HUMAN NUCLEAR PORE COMPLEX PROTEIN NUP153REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2g2b AIF1 nmr structure of the human allograft inflammatory factor 1 -1.0Å AUTH J.SONG,R.C.TYLER,C.L.NEWMAN,D.VINAROV,J.L.MARKLEYTITL NMR STRUCTURE OF THE HUMAN ALLOGRAFT INFLAMMATORYTITL 2 FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ii6 LIG4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Ripley’s K […]
General Structure Information 1xa6 CHN2 crystal structure of the human beta2-chimaerin 3.2Å AUTH B.CANAGARAJAH,F.C.LESKOW,J.Y.HO,H.MISCHAK,AUTH 2 L.F.SAIDI,M.G.KAZANIETZ,J.H.HURLEYTITL STRUCTURAL MECHANISM FOR LIPID ACTIVATION OF THETITL 2 RAC-SPECIFIC GAP, BETA2-CHIMAERIN.REF CELL(CAMBRIDGE,MASS.) V. 119 407 2004REFN ISSN 0092-8674PMID 15507211DOI 10.1016/J.CELL.2004.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2lul TEC solution nmr structure of ph domain of tyrosine-protein kinase tec from homo sapiens, northeast structural genomics consortium (nesg) target hr3504c -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,K.PEDERSON,Y.J.HUANG,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF PH DOMAIN OF TYROSINE-PROTEINTITL 2 KINASE TEC FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3504CREF TO […]
General Structure Information 1elw STIP1 crystal structure of the tpr1 domain of hop in complex with a hsc70 peptide 1.6Å AUTH C.SCHEUFLER,A.BRINKER,G.BOURENKOV,S.PEGORARO,AUTH 2 L.MORODER,H.BARTUNIK,F.U.HARTL,I.MOAREFITITL STRUCTURE OF TPR DOMAIN-PEPTIDE COMPLEXES:TITL 2 CRITICAL ELEMENTS IN THE ASSEMBLY OF THETITL 3 HSP70-HSP90 MULTICHAPERONE MACHINEREF CELL(CAMBRIDGE,MASS.) V. 101 199 2000REFN ISSN 0092-8674PMID 10786835DOI 10.1016/S0092-8674(00)80830-2 Variant Set Distributions Mapped Variants