Assessment of Structural Intolerance and Durability
General Structure Information 3frs IST1 structure of human ist1(ntd) (residues 1-189)(p43212) 2.61Å AUTH M.BAJOREK,H.L.SCHUBERT,J.MCCULLOUGH,C.LANGELIER,D.M.ECKERT,AUTH 2 W.M.STUBBLEFIELD,N.T.UTER,D.G.MYSZKA,C.P.HILL,W.I.SUNDQUISTTITL STRUCTURAL BASIS FOR ESCRT-III PROTEIN AUTOINHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 16 754 2009REFN ISSN 1545-9993PMID 19525971DOI 10.1038/NSMB.1621 Variant Set Distributions Mapped Variants
General Structure Information 1jkw CCNH structure of cyclin mcs2 2.6Å AUTH G.ANDERSEN,A.POTERSZMAN,J.M.EGLY,D.MORAS,AUTH 2 J.C.THIERRYTITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN H.REF FEBS LETT. V. 397 65 1996REFN ISSN 0014-5793PMID 8941715DOI 10.1016/S0014-5793(96)01143-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2hgm HNRNPF nmr structure of the second qrrm domain of human hnrnp f -1.0Å AUTH C.DOMINGUEZ,F.H.ALLAINTITL NMR STRUCTURE OF THE THREE QUASI RNA RECOGNITIONTITL 2 MOTIFS (QRRMS) OF HUMAN HNRNP F AND INTERACTIONTITL 3 STUDIES WITH BCL-X G-TRACT RNA: A NOVEL MODE OFTITL 4 RNA RECOGNITION.REF NUCLEIC ACIDS RES. V. 34 3634 […]
General Structure Information 2fu5 RABIF structure of rab8 in complex with mss4 2.0Å AUTH A.ITZEN,O.PYLYPENKO,R.S.GOODY,K.ALEXANDROV,A.RAKTITL NUCLEOTIDE EXCHANGE VIA LOCAL PROTEINTITL 2 UNFOLDING-STRUCTURE OF RAB8 IN COMPLEX WITH MSS4REF EMBO J. V. 25 1445 2006REFN ISSN 0261-4189PMID 16541104DOI 10.1038/SJ.EMBOJ.7601044 Variant Set Distributions Mapped Variants
General Structure Information 2pfi CLCNKA crystal structure of the cytoplasmic domain of the human chloride channel clc-ka 1.6Å AUTH S.MARKOVIC,R.DUTZLERTITL THE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THETITL 2 CHLORIDE CHANNEL CLC-KA REVEALS A CONSERVEDTITL 3 INTERACTION INTERFACE.REF STRUCTURE V. 15 715 2007REFN ISSN 0969-2126PMID 17562318DOI 10.1016/J.STR.2007.04.013 Variant Set Distributions Mapped Variants
General Structure Information 1x0h IQGAP1 solution structure of the carboxyl-terminal rgc domain in human iqgap1 -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CARBOXYL-TERMINAL RGCTITL 2 DOMAIN IN HUMAN IQGAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e37 FNTA protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 1.8Å AUTH M.A.HAST,S.FLETCHER,C.G.CUMMINGS,E.E.PUSATERI,AUTH 2 M.A.BLASKOVICH,K.RIVAS,M.H.GELB,W.C.VAN VOORHIS,AUTH 3 S.M.SEBTI,A.D.HAMILTON,L.S.BEESETITL STRUCTURAL BASIS FOR BINDING AND SELECTIVITY OFTITL 2 ANTIMALARIAL AND ANTICANCER ETHYLENEDIAMINETITL 3 INHIBITORS TO PROTEIN FARNESYLTRANSFERASE.REF CHEM.BIOL. V. 16 181 2009REFN ISSN 1074-5521PMID 19246009DOI 10.1016/J.CHEMBIOL.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3q2u GLIPR1 structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs. 1.85Å AUTH O.A.ASOJO,R.A.KOSKI,N.BONAFETITL STRUCTURAL STUDIES OF HUMAN GLIOMA PATHOGENESIS-RELATEDTITL 2 PROTEIN 1.REF ACTA CRYSTALLOGR.,SECT.D V. 67 847 2011REFN ISSN 0907-4449PMID 21931216DOI 10.1107/S0907444911028198 Variant Set Distributions Mapped Variants
General Structure Information 2d5r TOB1 crystal structure of a tob-hcaf1 complex 2.5Å AUTH M.HORIUCHI,K.TAKEUCHI,N.NODA,N.MUROYA,T.SUZUKI,AUTH 2 T.NAKAMURA,J.KAWAMURA-TSUZUKU,K.TAKAHASI,AUTH 3 T.YAMAMOTO,F.INAGAKITITL STRUCTURAL BASIS FOR THE ANTIPROLIFERATIVE ACTIVITYTITL 2 OF THE TOB-HCAF1 COMPLEX.REF J.BIOL.CHEM. V. 284 13244 2009REFN ISSN 0021-9258PMID 19276069DOI 10.1074/JBC.M809250200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants