Assessment of Structural Intolerance and Durability
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 1xke RANBP2 solution structure of the second ran-binding domain from human ranbp2 -1.0Å AUTH J.P.GEYER,R.DOKER,W.KREMER,X.ZHAO,J.KUHLMANN,AUTH 2 H.R.KALBITZERTITL SOLUTION STRUCTURE OF THE RAN-BINDING DOMAIN 2 OFTITL 2 RANBP2 AND ITS INTERACTION WITH THE C TERMINUS OFTITL 3 RAN.REF J.MOL.BIOL. V. 348 711 2005REFN ISSN 0022-2836PMID 15826666DOI 10.1016/J.JMB.2005.02.033 Variant Set Distributions Mapped Variants
General Structure Information 1z57 CLK1 crystal structure of human clk1 in complex with 10z-hymenialdisine 1.7Å AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2cpq FXR1 solution structure of the n-terminal kh domain of human fxr1 -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL KH DOMAIN OFTITL 2 HUMAN FXR1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c0m PEX5 apo form of the tpr domain of the pex5p receptor 2.5Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 1oni HRSP12 crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the yjgf/uk114 protein family 1.9Å AUTH B.A.MANJASETTY,H.DELBRUCK,D.T.PHAM,U.MUELLER,AUTH 2 M.FIEBER-ERDMANN,C.SCHEICH,V.SIEVERT,K.BUSSOW,F.H.NIESEN,AUTH 3 W.WEIHOFEN,B.LOLL,W.SAENGER,U.HEINEMANN,F.H.NEISENTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PROTEIN HP14.5.REF PROTEINS V. 54 797 2004REFN ISSN 0887-3585PMID 14997576DOI 10.1002/PROT.10619 Variant Set Distributions […]
General Structure Information 1i49 ARFIP2 crystal structure analysis of arfaptin 2.8Å AUTH C.TARRICONE,B.XIAO,N.JUSTIN,P.A.WALKER,K.RITTINGER,AUTH 2 S.J.GAMBLIN,S.J.SMERDONTITL THE STRUCTURAL BASIS OF ARFAPTIN-MEDIATEDTITL 2 CROSS-TALK BETWEEN RAC AND ARF SIGNALLING PATHWAYS.REF NATURE V. 411 215 2001REFN ISSN 0028-0836PMID 11346801DOI 10.1038/35075620 Variant Set Distributions Mapped Variants
General Structure Information 4avp ETV1 crystal structure of the dna-binding domain of human etv1. 1.82Å AUTH C.D.O.COOPER,J.A.NEWMAN,H.AITKENHEAD,C.K.ALLERSTON,AUTH 2 O.GILEADITITL STRUCTURES OF THE ETS DOMAINS OF TRANSCRIPTION FACTORS ETV1,TITL 2 ETV4, ETV5 AND FEV: DETERMINANTS OF DNA BINDING AND REDOXTITL 3 REGULATION BY DISULFIDE BOND FORMATION.REF J.BIOL.CHEM. V. 290 13692 2015REFN ISSN 0021-9258PMID 25866208DOI 10.1074/JBC.M115.646737 Variant […]
General Structure Information 4mbs CCR5 crystal structure of the ccr5 chemokine receptor 2.71Å AUTH Q.TAN,Y.ZHU,J.LI,Z.CHEN,G.W.HAN,I.KUFAREVA,T.LI,L.MA,AUTH 2 G.FENALTI,J.LI,W.ZHANG,X.XIE,H.YANG,H.JIANG,V.CHEREZOV,AUTH 3 H.LIU,R.C.STEVENS,Q.ZHAO,B.WUTITL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR-HIV ENTRY INHIBITORTITL 2 MARAVIROC COMPLEX.REF SCIENCE V. 341 1387 2013REFN ISSN 0036-8075PMID 24030490DOI 10.1126/SCIENCE.1241475 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1usd VASP human vasp tetramerisation domain l352m 1.7Å AUTH K.KUHNEL,T.JARCHAU,E.WOLF,I.SCHLICHTING,U.WALTER,AUTH 2 A.WITTINGHOFER,S.V.STRELKOVTITL THE VASP TETRAMERIZATION DOMAIN IS A RIGHT-HANDEDTITL 2 COILED COIL BASED ON A 15-RESIDUE REPEATREF PROC.NATL.ACAD.SCI.USA V. 101 17027 2004REFN ISSN 0027-8424PMID 15569942DOI 10.1073/PNAS.0403069101 Variant Set Distributions Mapped Variants