General Structure Information
| PDB ID | 4mbs |
| HGNC Gene Label(s) | CCR5 |
| Structure Name | crystal structure of the ccr5 chemokine receptor |
| Resolution | 2.71Å |
| Reference | AUTH Q.TAN,Y.ZHU,J.LI,Z.CHEN,G.W.HAN,I.KUFAREVA,T.LI,L.MA,AUTH 2 G.FENALTI,J.LI,W.ZHANG,X.XIE,H.YANG,H.JIANG,V.CHEREZOV,AUTH 3 H.LIU,R.C.STEVENS,Q.ZHAO,B.WUTITL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR-HIV ENTRY INHIBITORTITL 2 MARAVIROC COMPLEX.REF SCIENCE V. 341 1387 2013REFN ISSN 0036-8075PMID 24030490DOI 10.1126/SCIENCE.1241475 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 292 |
| Number Of SNVs | 90 |
| Number Of Permutations | 17457 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.15 |
| p-value | 0.04 |
COSMIC
| Number Of Residues | 292 |
| Number Of SNVs | 16 |
| Number Of Permutations | 14416 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.1 |
| p-value | 0.148 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 90 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.102 |
| p-value | 0.472 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
