Assessment of Structural Intolerance and Durability
General Structure Information 2a5g ARF6 cholera toxin a1 subunit bound to arf6(q67l) 2.66Å AUTH C.J.ONEAL,M.G.JOBLING,R.K.HOLMES,W.G.HOLTITL STRUCTURAL BASIS FOR THE ACTIVATION OF CHOLERA TOXIN BYTITL 2 HUMAN ARF6-GTP.REF SCIENCE V. 309 1093 2005REFN ISSN 0036-8075PMID 16099990DOI 10.1126/SCIENCE.1113398 Variant Set Distributions Mapped Variants
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1bi8 CDKN2D mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Mapped Variants
General Structure Information 2j1k CXADR cav-2 fibre head in complex with car d1 2.3Å AUTH E.SEIRADAKE,H.LORTAT-JACOB,O.BILLET,E.J.KREMER,S.CUSACKTITL STRUCTURAL AND MUTATIONAL ANALYSIS OF HUMAN AD37 AND CANINETITL 2 ADENOVIRUS 2 FIBER HEADS IN COMPLEX WITH THE D1 DOMAIN OFTITL 3 COXSACKIE AND ADENOVIRUS RECEPTOR.REF J.BIOL.CHEM. V. 281 33704 2006REFN ISSN 0021-9258PMID 16923808DOI 10.1074/JBC.M605316200 Variant Set Distributions Mapped […]
General Structure Information 3q7q RRAD crystal structure of rad g-domain q148a-gtp analog complex 2.3Å AUTH Y.SASSON,L.NAVON-PERRY,D.HUPPERT,J.A.HIRSCHTITL RGK FAMILY G-DOMAIN:GTP ANALOG COMPLEX STRUCTURES ANDTITL 2 NUCLEOTIDE-BINDING PROPERTIES.REF J.MOL.BIOL. V. 413 372 2011REFN ISSN 0022-2836PMID 21903096DOI 10.1016/J.JMB.2011.08.017 Variant Set Distributions Mapped Variants
General Structure Information 3phd UBA52 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants
General Structure Information 2ovc KCNQ4 crystal structure of a coiled-coil tetramerization domain from kv7.4 channels 2.07Å AUTH R.J.HOWARD,K.A.CLARK,J.M.HOLTON,D.L.MINORTITL STRUCTURAL INSIGHT INTO KCNQ (KV7) CHANNEL ASSEMBLY ANDTITL 2 CHANNELOPATHY.REF NEURON V. 53 663 2007REFN ISSN 0896-6273PMID 17329207DOI 10.1016/J.NEURON.2007.02.010 Variant Set Distributions Mapped Variants
General Structure Information 3e1y ETF1 crystal structure of human erf1/erf3 complex 3.8Å AUTH Z.CHENG,K.SAITO,A.V.PISAREV,M.WADA,V.P.PISAREVA,T.V.PESTOVA,AUTH 2 M.GAJDA,A.ROUND,C.KONG,M.LIM,Y.NAKAMURA,D.I.SVERGUN,K.ITO,AUTH 3 H.SONGTITL STRUCTURAL INSIGHTS INTO ERF3 AND STOP CODON RECOGNITION BYTITL 2 ERF1REF GENES DEV. V. 23 1106 2009REFN ISSN 0890-9369PMID 19417105DOI 10.1101/GAD.1770109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gd8 AQP4 crystal structure of human aquaporin 4 at 1.8 and its mechanism of conductance 1.8Å AUTH J.D.HO,R.YEH,A.SANDSTROM,I.CHORNY,W.E.HARRIES,R.A.ROBBINS,AUTH 2 L.J.MIERCKE,R.M.STROUDTITL CRYSTAL STRUCTURE OF HUMAN AQUAPORIN 4 AT 1.8 A AND ITSTITL 2 MECHANISM OF CONDUCTANCE.REF PROC.NATL.ACAD.SCI.USA V. 106 7437 2009REFN ISSN 0027-8424PMID 19383790DOI 10.1073/PNAS.0902725106 Variant Set Distributions Mapped Variants
General Structure Information 3nkx YWHAZ impaired binding of 14-3-3 to raf1 is linked to noonan and leopard syndrome 2.4Å AUTH M.MOLZAN,B.SCHUMACHER,C.OTTMANN,A.BALJULS,L.POLZIEN,AUTH 2 M.WEYAND,P.THIEL,R.ROSE,M.ROSE,P.KUHENNE,M.KAISER,U.R.RAPP,AUTH 3 J.KUHLMANN,C.OTTMANNTITL IMPAIRED BINDING OF 14-3-3 TO C-RAF IN NOONAN SYNDROMETITL 2 SUGGESTS NEW APPROACHES IN DISEASES WITH INCREASED RASTITL 3 SIGNALINGREF MOL.CELL.BIOL. V. 30 4698 2010REFN ISSN 0270-7306PMID 20679480DOI 10.1128/MCB.01636-09 Variant […]