Assessment of Structural Intolerance and Durability
General Structure Information 1yg5 HBA2 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1yg5 HBA1 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1z0a RAB2A gdp-bound rab2a gtpase 2.12Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 4bw5 KCNK10 crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) 3.4Å AUTH A.C.W.PIKE,A.MACKENZIE,C.MCCLENAGHAN,P.ARYAL,L.DONG,AUTH 2 A.QUIGLEY,M.GRIEBEN,S.GOUBIN,S.MUKHOPADHYAY,G.F.RUDA,AUTH 3 M.V.CLAUSEN,L.CAO,P.E.BRENNAN,N.A.BURGESS-BROWN,AUTH 4 M.S.P.SANSOM,S.J.TUCKER,E.P.CARPENTERTITL K2P CHANNEL GATING MECHANISMS REVEALED BY STRUCTURES OFTITL 2 TREK-2 AND A COMPLEX WITH PROZACREF SCIENCE V. 347 1256 2015REFN ISSN 0036-8075PMID 25766236DOI 10.1126/SCIENCE.1261512 Variant Set Distributions Ripley’s K […]
General Structure Information 1hur ARF1 human adp-ribosylation factor 1 complexed with gdp, full length non-myristoylated 2.0Å AUTH J.C.AMOR,D.H.HARRISON,R.A.KAHN,D.RINGETITL STRUCTURE OF THE HUMAN ADP-RIBOSYLATION FACTOR 1TITL 2 COMPLEXED WITH GDP.REF NATURE V. 372 704 1994REFN ISSN 0028-0836PMID 7990966DOI 10.1038/372704A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2br9 YWHAE 14-3-3 protein epsilon (human) complexed to peptide 1.75Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kfm GNB1 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kfm GNG2 crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits 3.45Å AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 Variant Set Distributions Mapped Variants
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2v37 CDH13 solution structure of the n-terminal extracellular domain of human t-cadherin -1.0Å AUTH S.A.DAMES,E.J.BANG,D.HAEUSSINGER,T.AHRENS,J.ENGEL,AUTH 2 S.GRZESIEKTITL INSIGHTS INTO THE LOW ADHESIVE CAPACITY OF HUMANTITL 2 T- CADHERIN FROM THE NMR STRUCTURE OF ITSTITL 3 N-TERMINAL EXTRACELLULAR DOMAIN.REF J.BIOL.CHEM. V. 283 23485 2008REFN ISSN 0021-9258PMID 18550521DOI 10.1074/JBC.M708335200 Variant Set Distributions Mapped Variants