General Structure Information
| PDB ID | 4bw5 |
| HGNC Gene Label(s) | KCNK10 |
| Structure Name | crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) |
| Resolution | 3.4Å |
| Reference | AUTH A.C.W.PIKE,A.MACKENZIE,C.MCCLENAGHAN,P.ARYAL,L.DONG,AUTH 2 A.QUIGLEY,M.GRIEBEN,S.GOUBIN,S.MUKHOPADHYAY,G.F.RUDA,AUTH 3 M.V.CLAUSEN,L.CAO,P.E.BRENNAN,N.A.BURGESS-BROWN,AUTH 4 M.S.P.SANSOM,S.J.TUCKER,E.P.CARPENTERTITL K2P CHANNEL GATING MECHANISMS REVEALED BY STRUCTURES OFTITL 2 TREK-2 AND A COMPLEX WITH PROZACREF SCIENCE V. 347 1256 2015REFN ISSN 0036-8075PMID 25766236DOI 10.1126/SCIENCE.1261512 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 254 |
| Number Of SNVs | 50 |
| Number Of Permutations | 43514 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.357 |
| p-value | 0.082 |
COSMIC
| Number Of Residues | 254 |
| Number Of SNVs | 7 |
| Number Of Permutations | 6861 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.429 |
| p-value | 0.704 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.156 |
| p-value | 0.58 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
