Assessment of Structural Intolerance and Durability
General Structure Information 1wxt EPS8L3 solution structure of the sh3 domain of human hypothetical protein flj21522 -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ21522REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n9u CPSF7 crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of human cleavage factor im 1.92Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNITTITL 2 AND THE […]
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3q2t CPSF6 crystal structure of cfim68 rrm/cfim25/rna complex 3.06Å AUTH Q.YANG,M.COSENO,G.M.GILMARTIN,S.DOUBLIETITL CRYSTAL STRUCTURE OF A HUMAN CLEAVAGE FACTORTITL 2 CFI(M)25/CFI(M)68/RNA COMPLEX PROVIDES AN INSIGHT INTOTITL 3 POLY(A) SITE RECOGNITION AND RNA LOOPING.REF STRUCTURE V. 19 368 2011REFN ISSN 0969-2126PMID 21295486DOI 10.1016/J.STR.2010.12.021 Variant Set Distributions Mapped Variants
General Structure Information 4jon CEP170 crystal structure of a centrosomal protein 170kda, transcript variant beta (cep170) from homo sapiens at 2.15 a resolution (psi community target, sundstrom) 2.15Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A CENTROSOMAL PROTEIN 170KDA,TITL 2 TRANSCRIPT VARIANT BETA (CEP170) FROM HOMO SAPIENS AT 2.15 ATITL 3 RESOLUTION […]
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eho GINS1 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 4hxi CUL3 crystal structure of klhl3/cul3 complex 3.51Å AUTH A.X.JI,G.G.PRIVETITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF KLHL3/CUL3TITL 2 COMPLEX AND IMPLICATIONS OF FHHT MUTATIONS IN CUL3 BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants