Assessment of Structural Intolerance and Durability
General Structure Information 2eho GINS2 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 4hxi KLHL3 crystal structure of klhl3/cul3 complex 3.51Å AUTH A.X.JI,G.G.PRIVETITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF KLHL3/CUL3TITL 2 COMPLEX AND IMPLICATIONS OF FHHT MUTATIONS IN CUL3 BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lkm MORF4L1 structural basis for molecular interactions involving mrg domains: implications in chromatin biology -1.0Å AUTH T.XIE,R.GRAVELINE,G.S.KUMAR,Y.ZHANG,A.KRISHNAN,G.DAVID,AUTH 2 I.RADHAKRISHNANTITL STRUCTURAL BASIS FOR MOLECULAR INTERACTIONS INVOLVING MRGTITL 2 DOMAINS: IMPLICATIONS IN CHROMATIN BIOLOGY.REF STRUCTURE V. 20 151 2012REFN ISSN 0969-2126PMID 22244764DOI 10.1016/J.STR.2011.10.019 Variant Set Distributions Mapped Variants
General Structure Information 3au5 MYO10 structure of the human myosin-x myth4-ferm cassette 2.55Å AUTH Y.HIRANO,T.HATANO,A.TAKAHASHI,M.TORIYAMA,N.INAGAKI,AUTH 2 T.HAKOSHIMATITL STRUCTURAL BASIS OF CARGO RECOGNITION BY THE MYOSIN-XTITL 2 MYTH4-FERM DOMAINREF EMBO J. V. 30 2734 2011REFN ISSN 0261-4189PMID 21642953DOI 10.1038/EMBOJ.2011.177 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 3ux3 FAM96A crystal structure of domain-swapped fam96a minor dimer 1.8Å AUTH K.-E.CHEN,A.A.RICHARDS,J.K.ARIFFIN,I.L.ROSS,M.J.SWEET,AUTH 2 S.KELLIE,B.KOBE,J.L.MARTINTITL THE MAMMALIAN DUF59 PROTEIN FAM96A FORMS TWO DISTINCT TYPESTITL 2 OF DOMAIN-SWAPPED DIMERREF ACTA CRYSTALLOGR.,SECT.D V. 68 637 2012REFN ISSN 0907-4449DOI 10.1107/S0907444912006592 Variant Set Distributions Mapped Variants
General Structure Information 3rwr NHEJ1 crystal structure of the human xrcc4-xlf complex 3.94Å AUTH N.S.ANDRES,C.WYMAN,M.MODESTI,M.S.JUNOPTITL STRUCTURE OF HUMAN XLF-XRCC4: ASSEMBLY OF A FUNCTIONAL DNATITL 2 REPAIR COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4nxt MIEF1 crystal structure of the cytosolic domain of human mid51 2.12Å AUTH V.RICHTER,C.S.PALMER,L.D.OSELLAME,A.P.SINGH,K.ELGASS,AUTH 2 D.A.STROUD,H.SESAKI,M.KVANSAKUL,M.T.RYANTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF MID51, A DYNAMINTITL 2 RECEPTOR REQUIRED FOR MITOCHONDRIAL FISSION.REF J.CELL BIOL. V. 204 477 2014REFN ISSN 0021-9525PMID 24515348DOI 10.1083/JCB.201311014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4gdk ATG5 crystal structure of human atg12~atg5 conjugate in complex with an n- terminal fragment of atg16l1 2.7Å AUTH C.OTOMO,Z.METLAGEL,G.TAKAESU,T.OTOMOTITL STRUCTURE OF THE HUMAN ATG12~ATG5 CONJUGATE REQUIRED FOR LC3TITL 2 LIPIDATION IN AUTOPHAGY.REF NAT.STRUCT.MOL.BIOL. V. 20 59 2013REFN ISSN 1545-9993PMID 23202584DOI 10.1038/NSMB.2431 Variant Set Distributions Mapped Variants
General Structure Information 2gwf RNF41 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]