General Structure Information
| PDB ID | 3rwr |
| HGNC Gene Label(s) | NHEJ1 |
| Structure Name | crystal structure of the human xrcc4-xlf complex |
| Resolution | 3.94Å |
| Reference | AUTH N.S.ANDRES,C.WYMAN,M.MODESTI,M.S.JUNOPTITL STRUCTURE OF HUMAN XLF-XRCC4: ASSEMBLY OF A FUNCTIONAL DNATITL 2 REPAIR COMPLEXREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 224 |
| Number Of SNVs | 65 |
| Number Of Permutations | 25369 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.11 |
| p-value | 0.42 |
COSMIC
| Number Of Residues | 224 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1206 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.167 |
| p-value | 0.928 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.143 |
| p-value | 0.839 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
