General Structure Information
| PDB ID | 4hxi |
| HGNC Gene Label(s) | KLHL3 |
| Structure Name | crystal structure of klhl3/cul3 complex |
| Resolution | 3.51Å |
| Reference | AUTH A.X.JI,G.G.PRIVETITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF KLHL3/CUL3TITL 2 COMPLEX AND IMPLICATIONS OF FHHT MUTATIONS IN CUL3 BINDINGREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 192 |
| Number Of SNVs | 34 |
| Number Of Permutations | 7803 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.045 |
| p-value | 0.381 |
ClinVar
| Number Of Residues | 192 |
| Number Of SNVs | 4 |
| Number Of Permutations | 546 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.075 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.305 |
| p-value | 0.058 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
