General Structure Information
| PDB ID | 2rgn |
| HGNC Gene Label(s) | ARHGEF25 |
| Structure Name | crystal structure of p63rhogef complex with galpha-q and rhoa |
| Resolution | 3.5Å |
| Reference | AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 327 |
| Number Of SNVs | 79 |
| Number Of Permutations | 39617 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.021 |
| p-value | 0.045 |
COSMIC
| Number Of Residues | 327 |
| Number Of SNVs | 4 |
| Number Of Permutations | 190 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.333 |
| p-value | 0.781 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 79 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.192 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
