Assessment of Structural Intolerance and Durability
General Structure Information 1fyx TLR2 crystal structure of p681h mutant of tir domain of human tlr2 2.8Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3puf RNASEH2A crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3nvq SEMA7A molecular mechanism of guidance cue recognition 2.4Å AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nvq PLXNC1 molecular mechanism of guidance cue recognition 2.4Å AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gh0 GFRA3 growth factor/receptor complex 1.92Å AUTH X.WANG,R.H.BALOH,J.MILBRANDT,K.C.GARCIATITL STRUCTURE OF ARTEMIN COMPLEXED WITH ITS RECEPTOR GFRALPHA3:TITL 2 CONVERGENT RECOGNITION OF GLIAL CELL LINE-DERIVEDTITL 3 NEUROTROPHIC FACTORS.REF STRUCTURE V. 14 1083 2006REFN ISSN 0969-2126PMID 16765900DOI 10.1016/J.STR.2006.05.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q32 JAK2 structure of janus kinase 2 with a pyrrolotriazine inhibitor 2.5Å AUTH L.S.HARIKRISHNAN,M.G.KAMAU,H.WAN,J.A.INGHRIM,K.ZIMMERMANN,AUTH 2 X.SANG,H.A.MASTALERZ,W.L.JOHNSON,G.ZHANG,L.J.LOMBARDO,AUTH 3 M.A.POSS,G.L.TRAINOR,J.S.TOKARSKI,M.V.LORENZI,D.YOU,AUTH 4 M.M.GOTTARDIS,K.F.BALDWIN,J.LIPPY,D.S.NIRSCHL,R.QIU,AUTH 5 A.V.MILLER,J.KHAN,J.S.SACK,A.V.PURANDARETITL PYRROLO[1,2-F]TRIAZINES AS JAK2 INHIBITORS: ACHIEVINGTITL 2 POTENCY AND SELECTIVITY FOR JAK2 OVER JAK3.REF BIOORG.MED.CHEM.LETT. V. 21 1425 2011REFN ISSN 0960-894XPMID 21282055DOI 10.1016/J.BMCL.2011.01.022 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4chb KLHL2 crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide 1.56Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]