General Structure Information
| PDB ID | 3bjc |
| HGNC Gene Label(s) | PDE5A |
| Structure Name | crystal structure of the pde5a catalytic domain in complex with a novel inhibitor |
| Resolution | 2.0Å |
| Reference | AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 311 |
| Number Of SNVs | 55 |
| Number Of Permutations | 27240 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.123 |
| p-value | 0.321 |
COSMIC
| Number Of Residues | 311 |
| Number Of SNVs | 3 |
| Number Of Permutations | 106 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.105 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.319 |
| p-value | 0.214 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
