Assessment of Structural Intolerance and Durability
General Structure Information 3r6n DSP crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain 2.95Å AUTH H.J.CHOI,W.I.WEISTITL CRYSTAL STRUCTURE OF A RIGID FOUR-SPECTRIN-REPEAT FRAGMENTTITL 2 OF THE HUMAN DESMOPLAKIN PLAKIN DOMAIN.REF J.MOL.BIOL. V. 409 800 2011REFN ISSN 0022-2836PMID 21536047DOI 10.1016/J.JMB.2011.04.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1ksw SRC structure of human c-src tyrosine kinase (thr338gly mutant) in complex with n6-benzyl adp 2.8Å AUTH L.A.WITUCKI,X.HUANG,K.SHAH,Y.LIU,S.KYIN,M.J.ECK,AUTH 2 K.M.SHOKATTITL MUTANT TYROSINE KINASES WITH UNNATURAL NUCLEOTIDETITL 2 SPECIFICITY RETAIN THE STRUCTURE ANDTITL 3 PHOSPHO-ACCEPTOR SPECIFICITY OF THE WILD-TYPETITL 4 ENZYME.REF CHEM.BIOL. V. 9 25 2002REFN ISSN 1074-5521PMID 11841936DOI 10.1016/S1074-5521(02)00091-1 Variant Set Distributions […]
General Structure Information 3e3b CSNK2A2 crystal structure of catalytic subunit of human protein kinase ck2alpha prime with a potent indazole-derivative inhibitor 3.2Å AUTH T.NAKANIWA,T.KINOSHITA,Y.SEKIGUCHI,T.TADA,AUTH 2 I.NAKANISHI,K.KITAURA,Y.SUZUKI,H.OHNO,A.HIRASAWA,AUTH 3 G.TSUJIMOTOTITL STRUCTURE OF HUMAN PROTEIN KINASE CK2ALPHA2 WITH ATITL 2 POTENT INDAZOLE-DERIVATIVE INHIBITORREF ACTA CRYSTALLOGR.,SECT.F V. 65 75 2009REFN ESSN 1744-3091PMID 19193990DOI 10.1107/S1744309108043194 Variant Set Distributions Ripley’s K […]
General Structure Information 3mtr NCAM1 crystal structure of the ig5-fn1 tandem of human ncam 1.8Å AUTH D.A.FOLEY,K.G.SWARTZENTRUBER,A.LAVIE,K.J.COLLEYTITL STRUCTURE AND MUTAGENESIS OF NEURAL CELL ADHESION MOLECULETITL 2 DOMAINS: EVIDENCE FOR FLEXIBILITY IN THE PLACEMENT OFTITL 3 POLYSIALIC ACID ATTACHMENT SITESREF J.BIOL.CHEM. V. 285 27360 2010REFN ISSN 0021-9258PMID 20573953DOI 10.1074/JBC.M110.140038 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kyo HLA-G crystal structure of hla-g presenting klpaqfyil peptide 1.7Å AUTH N.G.WALPOLE,L.KJER-NIELSEN,L.KOSTENKO,J.MCCLUSKEY,AUTH 2 A.G.BROOKS,J.ROSSJOHN,C.S.CLEMENTSTITL THE STRUCTURE AND STABILITY OF THE MONOMORPHIC HLA-G ARETITL 2 INFLUENCED BY THE NATURE OF THE BOUND PEPTIDEREF J.MOL.BIOL. V. 397 467 2010REFN ISSN 0022-2836PMID 20122941DOI 10.1016/J.JMB.2010.01.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x9n LIG1 crystal structure of human dna ligase i bound to 5-adenylated, nicked dna 3.0Å AUTH J.M.PASCAL,P.J.OBRIEN,A.E.TOMKINSON,T.ELLENBERGERTITL HUMAN DNA LIGASE I COMPLETELY ENCIRCLES AND PARTIALLYTITL 2 UNWINDS NICKED DNA.REF NATURE V. 432 473 2004REFN ISSN 0028-0836PMID 15565146DOI 10.1038/NATURE03082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ry6 FCGR2A complex of fcgammariia (cd32) and the fc of human igg1 3.8Å AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]